GEO DataSet Links for BioProject (Select 145853) - GEO DataSets

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Items: 2

Select item 2000312801.

Transcript level in F9 teratocarcinoma WT and RARalpha knockout in presence and absence of all-trans retinoic acid

(Submitter supplied) Retinoic acid receptors (RARs) α, β and γ are key regulators of embryonic development. Hematopoietic differentiation is regulated by RARα, and several types of leukemia show aberrant RARα activity. We demonstrate that RARα plays an important role in cellular memory and imprinting by regulating the CpG methylation status of specific promoter regions. We used microarrays to identify genes, which display differential expression in F9 RARalpha knockout (RARaKO) cells relative to F9 wt cells.

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4294
Platform:: GPL1261
12 Samples

Download data: CEL

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Accession:: GSE31280

ID:: 200031280

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 42942.

All-trans retinoic acid effect on retinoic acid receptor α-deficient F9 teratocarcinoma cells

Analysis of F9 teratocarcinoma cells depleted of retinoic acid receptor (RAR)α and treated with all trans retinoic acid (atRA) in the presence of cycloheximide. RARα translocation events are associated with acute promyelocytic leukemia (APL). Results provide insight into the role of RARα in APL.