GEO DataSet Links for BioProject (Select 119553) - GEO DataSets

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Items: 2

Select item 2000181981.

Expression profile of human T-ALL cell lines treated with DMSO or SAHM1

(Submitter supplied) NOTCH proteins regulate signaling pathways involved in cellular differentiation, proliferation and death. Overactive Notch signaling as been observed in numerous cancers and has been extensively studied in the context of T-cell acute lymphoblastic leukemia (T-ALL) where more than 50% of pateints harbour mutant NOTCH1. Small molecule modulators of these proteins would be important for understanding the role of NOTCH proteins in malignant and normal biological processes. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3717
Platform:: GPL570
12 Samples

Download data: CEL

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Accession:: GSE18198

ID:: 200018198

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 37172.

NOTCH antagonist SAHM1 effect on T-ALL cell lines

Analysis of HPB-ALL and KOPT-K1 cells treated with SAHM1, an antagonist of the NOTCH transcription factor. SAHM1 is an alpha-helical hydrocarbon stapled peptide derived from MAML1. Results provide insight into the specificity of the antagonistic effect of SAHM1 on gene expression driven by NOTCH.