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KAS-seq profiling captures transcription dynamics during oocyte maturation

(Submitter supplied) In fully grown oocytes, the genome is considered to be globally transcriptionally silenced. However, this conclusion is primarily derived from the results obtained through immunofluorescence staining or inferred from the highly condensed state of chromosomes, lacking more direct evidence. Here, by using a kethoxal-assisted single-stranded DNA sequencing (KAS-seq) approach, we investigated the landscape of single-strand DNA (ssDNA) throughout the genome and provided a readout of the activity and dynamics of transcription during oocyte meiotic maturation. more...
Organism:
Mus musculus
Type:
Other
Platform:
GPL24247
16 Samples
Download data: BW
Series
Accession:
GSE252350
ID:
200252350

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