(Submitter supplied) The availability of viral entry factors is a prerequisite for the cross-species transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Large-scale single-cell screening on animal cells is a powerful tool to reveal the expression patterns of viral entry genes for different hosts. But such exploration for SARS-CoV-2 remained limited. Here, we presented the broadest pan-species single-nucleus RNA sequencing study to date, covering 11 representative species in pets (cat, dog, hamster, lizard), livestock (goat, rabbit), poultry (duck, pigeon) and wildlife (pangolin, tiger, deer), from which we investigated the co-expression of ACE2 and TMPRSS2.
more...- Organism:
- Anas platyrhynchos; Canis lupus familiaris; Anolis carolinensis; Panthera tigris altaica; Columba livia; Felis catus; Capra aegagrus; Manis javanica; Cervus nippon taiouanus; Oryctolagus cuniculus; Mesocricetus auratus
- Type:
- Expression profiling by high throughput sequencing
- 11 related Platforms
- 29 Samples
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