GEO DataSets

(Submitter supplied) Paramyxoviruses (PMVs) exploit the host's translation machinery to enhance their replication. We found that the PMV matrix protein is crucial in this process, inhibiting host protein synthesis while boosting viral protein production. This occurs through interactions with the core exon-junction complex (cEJC), a key player in mRNA biogenesis. Disruption of this interaction using siRNA led to increased viral replication but did not affect other viruses like SARS-CoV-2. more...

Organism:

Human respirovirus 3; Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL16791 GPL34775

21 Samples

Download data: XLSX

(Submitter supplied) Effective methods for predicting COVID-19 disease trajectories are urgently needed. Here, enzyme-linked immunosorbent assay (ELISA) and coronavirus antigen microarray (COVAM) analysis mapped antibody epitopes in the plasma of COVID-19 patients (n = 86) experiencing a wide range of disease states. The experiments identified antibodies to a 21-residue epitope from nucleocapsid (termed Ep9) associated with severe disease, including admission to the intensive care unit (ICU), requirement for ventilators, or death. more...

Organism:

Homo sapiens; Human respiratory syncytial virus A; Dromedary camel coronavirus; Human orthorubulavirus 2; Human parainfluenza virus 4b; Influenza B virus; Human respirovirus 1; human metapneumovirus; Human respiratory syncytial virus B; Human adenovirus sp.; Human coronavirus 229E; Human respirovirus 3; Influenza A virus; Human coronavirus NL63; Severe acute respiratory syndrome-related coronavirus; Human coronavirus OC43; Human coronavirus HKU1; Severe acute respiratory syndrome coronavirus 2

Type:

Protein profiling by protein array

Platform:

GPL30021

90 Samples

Download data: TXT

(Submitter supplied) 60 antigens across respiratory virus subtypes, including 11 antigens from SARS-CoV-2 expressed in either baculovirus or HEK-293 cells. All antigens were supplied by Sino Biological Inc. Purified proteins were printed onto ONCYTE AVID nitrocellulose-coated slides (Grace Bio-Labs, Bend, OR) using an OmniGrid 100 microarray printer (GeneMachines). Protocol: See manufacturer website.

Organism:

Human coronavirus 229E; Human respirovirus 3; Human parainfluenza virus 4b; Influenza A virus; Influenza B virus; Human respirovirus 1; Human coronavirus OC43; human metapneumovirus; Human respiratory syncytial virus A; Human respiratory syncytial virus B; Human coronavirus NL63; Human coronavirus HKU1; Severe acute respiratory syndrome-related coronavirus; Human adenovirus sp.; Dromedary camel coronavirus; Human orthorubulavirus 2; Severe acute respiratory syndrome coronavirus 2

1 Series

90 Samples

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