txid1292253[Organism:exp] - GEO DataSets

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Items: 1 to 20 of 3175

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Select item 2002617221.

Identification of EV-responsive transcripts in the planarian Schmidtea mediterranea

(Submitter supplied) The roles of extracellular vesicles in animal models of regeneration are poorly characterized. The goal of this study was to identify differentially expressed transcripts in planarian flatworms after injection of buffer only or extracellular vesicles compared to uninjected animals.

Organism:: Schmidtea mediterranea

Type:: Expression profiling by high throughput sequencing

Platform:: GPL34306
24 Samples

Download data: TXT

Series

Accession:: GSE261722

ID:: 200261722

Select item 2002072732.

Tomo-Seq of Dugeisa japonica along AP axis

(Submitter supplied) In order to reveal temporal gene expression pattern in intact Dugesia japonica, we conducted high-thoriughput version of Tomo-Seq along the AP, DV, and LR axis.

Organism:: Dugesia japonica

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30183
157 Samples

Download data: CSV

Series

Accession:: GSE207273

ID:: 200207273

Select item 2002678653.

A niche-derived non-ribosomal peptide triggers planarian sexual development.

(Submitter supplied) Germ cells are regulated by local microenvironments (niches), which secrete instructive cues. Conserved developmental signaling molecules act as niche-derived regulatory factors, yet other types of niche signals remain to be identified. Single-cell RNA-sequencing of sexual planarians revealed niche cells expressing a non-ribosomal peptide synthetase (nrps). Inhibiting nrps led to loss of female reproductive organs and testis hyperplasia. more...

Organism:: Schmidtea mediterranea

Type:: Expression profiling by high throughput sequencing

Platform:: GPL29967
4 Samples

Download data: MTX, TSV

Series

Accession:: GSE267865

ID:: 200267865

PubMed Full text in PMC Similar studies

Select item 2002560324.

Multiplex single cell analysis of serotonergic neuron function in planarians reveals widespread effects in diverse cell types

(Submitter supplied) We used scRNA-seq to examine serotonergic function in asexual planarians. We profiled 47,292 single cell transcriptomes of planarian of 3 different RNAi categories: gfp(RNAi), lhx1/5-1(RNAi) and pitx(RNAi). We detected changes in cell type frequency and gene expression patterns in planarian of different knock-down conditions, capturing regulatory programs of distinct cell types in response to loss of serotonergic function.

Organism:: Schmidtea mediterranea

Type:: Expression profiling by high throughput sequencing

Platform:: GPL29967
5 Samples

Download data: MTX, TSV

Series

Accession:: GSE256032

ID:: 200256032

Select item 2002466815.

Allometry of cell types in planarians by single cell transcriptomics

(Submitter supplied) We used scRNA-seq to examine cell type allometry in asexual planarians. We profiled 28,738 single cell transcriptomes of planarian of 3 different sizes categories: small (S), medium (M) and large (L). We detected changes in cell type frequency and gene expression patterns in planarian of different sizes, capturing regulatory programs of distinct cell types in response to allometric scaling.

Organism:: Schmidtea mediterranea

Type:: Expression profiling by high throughput sequencing

Platform:: GPL29967
2 Samples

Download data: MTX, TSV

Series

Accession:: GSE246681

ID:: 200246681

Select item 2002239286.

RNA-Seq of X-ray irradiated planarians

(Submitter supplied) Time-course RNA-Seq of X-ray irradiated planarians Dugesia japonica.

Organism:: Dugesia japonica

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30183
18 Samples

Download data: CSV

Series

Accession:: GSE223928

ID:: 200223928

PubMed Similar studies

Select item 2002239297.

Resource of single cell gene expression profiles in a planarian Dugesia japonica

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Dugesia japonica

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL32771 GPL30183
19 Samples

Download data: CSV

Series

Accession:: GSE223929

ID:: 200223929

PubMed Similar studies

Select item 2002239278.

single cell RNA-Seq of Dugesia japonica

(Submitter supplied) A single cell RNA-Seq analysis of Dugesia japonica intact animals by TAS-Seq (Shichino et al, 2022)

Organism:: Dugesia japonica

Type:: Expression profiling by high throughput sequencing

Platform:: GPL32771
1 Sample

Download data: CSV

Series

Accession:: GSE223927

ID:: 200223927

PubMed Similar studies

Select item 2002164119.

Deciphering m6A dynamics at single-base level during planarian anterior-posterior (AP) axis specification [mRNA]

(Submitter supplied) We accomplished de novo transcriptome assembly for planarian Dugesia japonica.

Organism:: Dugesia japonica

Type:: Expression profiling by high throughput sequencing

Platform:: GPL32771
18 Samples

Download data: FASTA, XLSX

Series

Accession:: GSE216411

ID:: 200216411

PubMed Full text in PMC Similar studies

Select item 20021641010.

Deciphering m6A dynamics at single-base level during planarian anterior-posterior (AP) axis specification [m6A]

(Submitter supplied) We accomplished the m6A landscapes at single-base resolution with multiple time-points during AP axis regeneration for planarian Dugesia japonica.

Organism:: Dugesia japonica

Type:: Other

Platform:: GPL32771
19 Samples

Download data: FASTA, XLSX

Series

Accession:: GSE216410

ID:: 200216410

PubMed Full text in PMC Similar studies

Select item 20021641211.

Deciphering m6A dynamics at single-base level during planarian anterior-posterior (AP) axis specification

(Submitter supplied) Background: The establishment of the anterior-posterior (A-P) axis is a crucial step during tissue repair and regeneration. Despite the association reported recently of N6-methyladenosine (m6A) with regeneration, the mechanism underlying the regulation of m6A in A-P axis specification during regeneration remains unknown. Herein, we deciphered the m6A landscape at a single-base resolution at multiple time points during A-P axis regeneration and constructed the de novo transcriptome assembly of the Dugesia japonica planarian.

Organism:: Dugesia japonica

Type:: Other; Expression profiling by high throughput sequencing

Platform:: GPL32771
37 Samples

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Series

Accession:: GSE216412

ID:: 200216412

PubMed Full text in PMC Similar studies

Select item 20024151612.

aristaless-like homeobox-3 is wound induced in muscle and stem cells and is required for planarian head regeneration

(Submitter supplied) To investigate the role of alx-3 in activating wound-induced transciptional programs during anterior regneneraiton, control(RNAi) and alx-3(RNAi) planarians were amputated below the pharynx and were allowed to regenerate for 0.5 hours post-amputation (HPA), 6HPA, 24HPA, 48HPA and 72HPA. Intact animals were are also included.Tissue from tail fragments and intact animals was collected at each time point for RNA extraction and cDNA synthesis. more...

Organism:: Schmidtea mediterranea

Type:: Expression profiling by high throughput sequencing

Platform:: GPL29967
36 Samples

Download data: XLSX

Series

Accession:: GSE241516

ID:: 200241516

PubMed Full text in PMC Similar studies

Select item 20021213613.

High throughput expression-based phenotyping and RNAi screening reveals novel regulators of planarian stem cells

(Submitter supplied) The complexity of cell types and states revealed by scRNAseq cell atlases presents a challenge for the systematic analysis of fate determinants using traditional screening methodologies. Differentiation in the planarian Schmidtea mediterranea exemplifies this problem, as these animals continuously produce over 100 differentiated cell types for homeostasis and regeneration using adult pluripotent stem cells termed neoblasts. more...

Organism:: Schmidtea mediterranea

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21689
75 Samples

Download data: XLSX

Series

Accession:: GSE212136

ID:: 200212136

Select item 20023154814.

Depletion of 16S ribosomal RNA improves single-cell RNA-seq of planarians by DASH

(Submitter supplied) Single-cell transcriptomics (scRNA-seq) has revolutionized our understanding of cell types and states in various contexts, such as development and disease. Most methodology relies on poly(A) enrichment to selectively capture protein-coding polyadenylated transcripts, intending to exclude ribosomal transcripts that constitute >80% of the transcriptome. However, it is common for ribosomal transcripts to sneak into the library, which can add significant background by flooding libraries with irrelevant sequences. more...

Organism:: Schmidtea mediterranea

Type:: Expression profiling by high throughput sequencing

Platform:: GPL33372
9 Samples

Download data: MTX, TSV

Series

Accession:: GSE231548

ID:: 200231548

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Select item 20019252415.

Genome-wide analysis of planarian piRNAs

(Submitter supplied) Sample dataset for the described bioinformatic pipeline (piRNAnalyzer) comprising epidermal piRNA libraries of Schmidtea mediterranea

Organism:: Schmidtea mediterranea

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL21689
3 Samples

Download data: BW

Series

Accession:: GSE192524

ID:: 200192524

PubMed Similar studies

Select item 20020292816.

m6A Modification Regulates Planarian Regeneration [scRNA-seq]

(Submitter supplied) Regeneration is the regrowth of damaged tissues or organs, a vital mechanism in response to damages from primitive organisms to higher mammals. Planarian possesses active whole-body regenerative capability owning to its vast reservoir of adult stem cells, neoblasts, providing an ideal model to delineate the underlying mechanisms for regeneration. RNA N6-methyladenosine (m6A) modification participates in many biological processes, including stem cell self-renewal and differentiation, in particular the regeneration of hematopoietic stem cells and axons. more...

Organism:: Schmidtea mediterranea

Type:: Expression profiling by high throughput sequencing

Platform:: GPL29967
10 Samples

Download data: TXT

Series

Accession:: GSE202928

ID:: 200202928

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20017124917.

m6A Modification Regulates Planarian Regeneration [MeRIP-seq]

(Submitter supplied) The fundamental of regeneration process of invertebrates involves the renewal, differentiation and reprogramming of stem cell in an orchestrated manner. It has been known that N6-methyladenosine (m6A) regulates stem cell renewal and differentiation. It is still unclear if m6A is crucial for the regeneration at whole-organism level. Here, we demonstrate that wtap knockdown mediated m6A depletion impairs planarian regeneration upon amputation. more...

Organism:: Schmidtea mediterranea

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL29967
30 Samples

Download data: TXT

Series

Accession:: GSE171249

ID:: 200171249

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20017124718.

m6A Modification Regulates Planarian Regeneration [RNA-seq]

Organism:: Schmidtea mediterranea

Type:: Expression profiling by high throughput sequencing

Platform:: GPL29967
30 Samples

Download data: TXT

Series

Accession:: GSE171247

ID:: 200171247

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20017125319.

m6A Modification Promotes Planarian Regeneration

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Schmidtea mediterranea

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL29967
70 Samples

Download data

Series

Accession:: GSE171253

ID:: 200171253

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Select item 20022715520.

Identification of dysregulated transcripts in egr-2(RNAi) planarians

(Submitter supplied) egr-2 is an injury-responsive gene that is upregulated in the anterior of planarian tail fragments and required for intestinal remodeling. The goal of this study was to identify differentially expressed transcripts in the anterior region of egr-2(RNAi) tail fragments relative to egfp(RNAi) control fragments.

Organism:: Schmidtea mediterranea

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30113
24 Samples

Download data: TXT

Series

Accession:: GSE227155

ID:: 200227155

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