GEO DataSets

(Submitter supplied) Perivascular adipose tissue (PVAT) is thought to play a role in vascular homeostasis and in the pathogenesis of diseases of large vessels. We tested the hypothesis that locally restricted transcriptional profiles characterize the PVAT localized at the site of the obstruction of the abdominal aorta in peripheral artery disease (PAD) patients. By a genome-wide approach and a paired-samples design, we investigated the PVAT transcriptome of 11 PAD patients with occlusive and with stenotic abdominal aortic lesions. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

43 Samples

Download data: TXT

(Submitter supplied) Atherosclerosis is causally related to disturbed flow through low and oscillatory shear stress. In order to study the miR expression profile in atherosclerotic plaques induced by disturbed flow, partial ligation of the carotid artery was performed. This procedure results acutely in severly reduced blood flow and in stenotic lesion formation within 6 weeks in apoe-/- mice on a high fat diet. We compared the miR expression profile in partially ligated left carotid arteries with the untreated right carotid artery to identify miRs which are involved in plaque formation through flow disturbances.

Organism:

Mus musculus

Type:

Non-coding RNA profiling by array

Platform:

GPL11419

12 Samples

Download data: TXT