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Select item 2002772701.

3D-Printed PCL Scaffolds Loaded with bFGF and BMSCs(PCLMF) Enhance Tendon-Bone Healing in Rat Rotator Cuff Tears by Immunomodulation and Osteogenesis Promotion

(Submitter supplied) Rotator cuff tears are the most common conditions in sports medicine and attract increasing attention. Scar tissue healing at the tendon-bone interface results in a high rate of retears, making it a major challenge to enhance the healing of the rotator cuff tendon-bone interface. Biomaterials currently employed for tendon-bone healing in rotator cuff tears still exhibit limited efficacy. 3D printing, a promising technology, enables the customization of scaffold shapes and properties. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
6 Samples

Download data: XLS

Series

Accession:: GSE277270

ID:: 200277270

Select item 2002357222.

The copepod Eurytemora affinis as a relevant species to assess estuarine sediment toxicity by combining sub-individual and individual endpoints: effects on gene expression and swimming behavior

(Submitter supplied) Compared to freshwater ecosystems, the health status of estuarine waters remains little studied despite their importance for many species. They also represent a zone of interest for Human settlements that make them the final sink of pollution in both the water column and sediment. Once in sediments, pollutants could represent a threat to benthic as well as pelagic estuarine species through resuspension events. more...

Organism:: Eurytemora affinis

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30085
15 Samples

Download data: TSV

Series

Accession:: GSE235722

ID:: 200235722

Select item 2002723643.

Transfer of mitochondrial DNA into the nuclear genome during induced DNA breaks [c.MYC_DdCBE_ND4_TREX]

(Submitter supplied) Mitochondria serve as the cellular powerhouse, and their distinct DNA makes them a prospective target for gene editing to treat genetic disorders. However, the impact of genome editing on mitochondrial DNA (mtDNA) stability remains a mystery. Our study reveals previously unknown risks of genome editing that both nuclear and mitochondrial editing cause discernible transfer of mitochondrial DNA segments into the nuclear genome in various cell types including human cell lines, primary T cells, and mouse embryos. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL16791
24 Samples

Download data: TAB

Series

Accession:: GSE272364

ID:: 200272364

Select item 2002723604.

Transfer of mitochondrial DNA into the nuclear genome during induced DNA breaks [DdCBE_ND4_TREX]

Organism:: Homo sapiens

Type:: Other

Platform:: GPL16791
18 Samples

Download data: TAB

Series

Accession:: GSE272360

ID:: 200272360

Select item 2002618655.

Transfer of mitochondrial DNA into the nuclear genome during gene editing [target sequencing]

(Submitter supplied) Mitochondria serve as the cellular powerhouse, and their distinct DNA makes them a prospective target for gene editing to treat genetic disorders. However, the impact of genome editing on mitochondrial DNA (mtDNA) stability remains a mystery. Our study reveals previously unknown risks of genome editing that both nuclear and mitochondrial editing cause broad transfer of mitochondrial DNA segments into the nuclear genome in various cell types including human cell lines, primary T cells, and mouse embryos. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL16791
15 Samples

Download data: BED

Series

Accession:: GSE261865

ID:: 200261865

Select item 2002618646.

Transfer of mitochondrial DNA into the nuclear genome during gene editing [PEM-Seq MT stress]

(Submitter supplied) Mitochondria serve as the cellular powerhouse, and their distinct DNA makes them a prospective target for gene editing to treat genetic disorders. However, the impact of genome editing on mitochondrial DNA (mtDNA) stability remains a mystery. Our study reveals previously unknown risks of genome editing that both nuclear and mitochondrial editing cause broad transfer of mitochondrial DNA segments into the nuclear genome in various cell types including human cell lines, primary T cells, and mouse embryos. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL16791
9 Samples

Download data: TAB

Series

Accession:: GSE261864

ID:: 200261864

Select item 2002618617.

Transfer of mitochondrial DNA into the nuclear genome during gene editing [PEM-Seq mtDNA breaks]

(Submitter supplied) Mitochondria serve as the cellular powerhouse, and their distinct DNA makes them a prospective target for gene editing to treat genetic disorders. However, the impact of genome editing on mitochondrial DNA (mtDNA) stability remains a mystery. Our study reveals previously unknown risks of genome editing that both nuclear and mitochondrial editing cause broad transfer of mitochondrial DNA segments into the nuclear genome in various cell types including human cell lines, primary T cells, and mouse embryos. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL16791
6 Samples

Download data: TAB

Series

Accession:: GSE261861

ID:: 200261861

Select item 2002485128.

Transfer of mitochondrial DNA into the nuclear genome during gene editing [ND5.1 PEM-seq]

(Submitter supplied) Mitochondria serve as the cellular powerhouse, and their distinct DNA makes them a prospective target for gene editing to treat genetic disorders. However, the impact of genome editing on mitochondrial DNA (mtDNA) stability remains a mystery. Our study reveals previously unknown risks of genome editing that both nuclear and mitochondrial editing cause broad transfer of mitochondrial DNA segments into the nuclear genome in various cell types including human cell lines, primary T cells, and mouse embryos. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL16791
9 Samples

Download data: TAB

Series

Accession:: GSE248512

ID:: 200248512

Select item 2002485119.

Transfer of mitochondrial DNA into the nuclear genome during gene editing [ND5.3 PEM-seq]

(Submitter supplied) Mitochondria serve as the cellular powerhouse, and their distinct DNA makes them a prospective target for gene editing to treat genetic disorders. However, the impact of genome editing on mitochondrial DNA (mtDNA) stability remains a mystery. Our study reveals previously unknown risks of genome editing that both nuclear and mitochondrial editing cause broad transfer of mitochondrial DNA segments into the nuclear genome in various cell types including human cell lines, primary T cells, and mouse embryos. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL16791
6 Samples

Download data: TAB

Series

Accession:: GSE248511

ID:: 200248511

Select item 20024851010.

Transfer of mitochondrial DNA into the nuclear genome during gene editing [mitoTALEN_ND4 PEM-seq]

(Submitter supplied) Mitochondria serve as the cellular powerhouse, and their distinct DNA makes them a prospective target for gene editing to treat genetic disorders. However, the impact of genome editing on mitochondrial DNA (mtDNA) stability remains a mystery. Our study reveals previously unknown risks of genome editing that both nuclear and mitochondrial editing cause broad transfer of mitochondrial DNA segments into the nuclear genome in various cell types including human cell lines, primary T cells, and mouse embryos. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL16791
6 Samples

Download data: TAB

Series

Accession:: GSE248510

ID:: 200248510

Select item 20024850911.

Transfer of mitochondrial DNA into the nuclear genome during gene editing [CBE_ND4 PEM-seq]

(Submitter supplied) Mitochondria serve as the cellular powerhouse, and their distinct DNA makes them a prospective target for gene editing to treat genetic disorders. However, the impact of genome editing on mitochondrial DNA (mtDNA) stability remains a mystery. Our study reveals previously unknown risks of genome editing that both nuclear and mitochondrial editing cause broad transfer of mitochondrial DNA segments into the nuclear genome in various cell types including human cell lines, primary T cells, and mouse embryos. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL16791
6 Samples

Download data: TAB

Series

Accession:: GSE248509

ID:: 200248509

Select item 20024816412.

Transfer of mitochondrial DNA into the nuclear genome during gene editing [PEM-seq]

(Submitter supplied) Mitochondria serve as the cellular powerhouse, and their distinct DNA makes them a prospective target for gene editing to treat genetic disorders. However, the impact of genome editing on mitochondrial DNA (mtDNA) stability remains a mystery. Our study reveals previously unknown risks of genome editing that both nuclear and mitochondrial editing cause broad transfer of mitochondrial DNA segments into the nuclear genome in various cell types including human cell lines, primary T cells, and mouse embryos. more...

Organism:: Mus musculus

Type:: Other

Platform:: GPL17021
21 Samples

Download data: TAB

Series

Accession:: GSE248164

ID:: 200248164

Select item 20027714713.

Patient-Derived Tumor Organoid and Fibroblast Assembloid Models for interrogation of the tumor microenvironment in Esophageal Adenocarcinoma

(Submitter supplied) The tumor microenvironment (TME) comprises all non-tumor elements of cancer and strongly influences disease progression and phenotype. To understand tumor biology and accurately test new therapeutic strategies, representative models should contain both tumor cells and normal cells of the TME. Here we describe and characterize co-culture tumor-derived organoids and cancer-associated fibroblasts (CAFs), a major component of the TME, in matrix-embedded assembloid models of esophageal adenocarcinoma (EAC). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
8 Samples

Download data: TXT

Series

Accession:: GSE277147

ID:: 200277147

Select item 20024269214.

Predicting Oncology Drug-Induced Cardiotoxicity with Donor-Specific iPSC-CMs – Model Verification with Doxorubicin

(Submitter supplied) Many oncology drugs have been found to induce cardiotoxicity in a subset of patients, which significantly limits their clinical use and impedes the benefit of lifesaving anti-cancer treatments. Human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) carry donor-specific genetic information and have been proposed for explore the inter-individual difference in oncology drug-induced cardiotoxicity. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
88 Samples

Download data: COUNTS, TXT

Series

Accession:: GSE242692

ID:: 200242692

Select item 20025021915.

Direct mapping of G-quadruplex anchored 3D chromatin structure via ViCAR

(Submitter supplied) We developed ViCAR (viewpoint HiCAR), a technique that uses antibody-based capture of genome features and their interacting chromatin domains. ViCAR uncovers numerous cell-type-specific G4-dependent enhancer-promoter interactions and is easily extended to other features such as histone marks. ViCAR represents a practical and powerful tool to explore the relationship between epigenetic marks and 3D genome interactomes.

Organism:: Homo sapiens; Mus musculus

Type:: Other

Platforms:: GPL18573 GPL30173 GPL30172
79 Samples

Download data: BED, BW, TBI, XLSX

Series

Accession:: GSE250219

ID:: 200250219

PubMed Full text in PMC Similar studies

Select item 20026369616.

The unique catalytic properties of PSAT1 mediate metabolic adaptation to glutamine blockade

(Submitter supplied) Cultured cancer cells frequently rely on the consumption of glutamine and its subsequent hydrolysis to glutamate by the mitochondrial enzyme glutaminase (GLS). However, this metabolic addiction can be lost in the tumor microenvironment (TME), rendering GLS inhibitors ineffective in the clinic. Here, we show that seemingly glutamine-addicted breast cancer cells ultimately adapt to chronic glutamine starvation, or targeted GLS inhibition, via the AMPK-mediated upregulation of the serine synthesis pathway (SSP). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
6 Samples

Download data: CSV, TABULAR

Series

Accession:: GSE263696

ID:: 200263696

Select item 20025349317.

RNA-Seq experiment of primary hepatic stellate cells (HSCs) and LX-2 cell line treated with TGFb

(Submitter supplied) Liver fibrosis stands as the most prominent predictor of overall mortality in non-alcoholic steatohepatitis (NASH). The fibrotic liver features excessive deposition of extracellular matrix (ECM), primarily produced from "activated" hepatic stellate cells (HSCs). Whereas targeting HSC in fibrosis therapeutics shows promise, the current identification of human genetic regulators driving HSC activation is far from complete. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21290
12 Samples

Download data: TXT

Series

Accession:: GSE253493

ID:: 200253493

PubMed Full text in PMC Similar studies

Select item 20026964918.

MHC II Heterozygosity Limits T Cell Receptor Variability in CD4 T Cells

(Submitter supplied) αβ T cell receptor (TCR) V(D)J genes code for billions of TCR combinations. However only some appear on peripheral T cells in any individual because, to mature, thymocytes must react with low affinity but not high affinity with thymus expressed MHC/peptides. MHC proteins are very polymorphic. Different alleles bind different peptides. Therefore any individual might express many different MHC alleles to ensure that some peptides from an invader are bound to MHC and activate T cells. more...

Organism:: Mus musculus

Type:: Other

4 related Platforms
70 Samples

Download data: CSV

Series

Accession:: GSE269649

ID:: 200269649

PubMed Similar studies

Select item 20023636019.

Tracking-seq reveals the heterogeneity of off-target effects in CRISPR/Cas9-mediated genome editing

(Submitter supplied) The continued development of novel genome editors calls for a universal method to analyze their off-target effects. Here we describe a versatile method, called Tracking-seq, for in situ identification of off-target effects that is broadly applicable to common genome-editing tools, including Cas9, base editors and prime editors. Through tracking replication protein A (RPA)-bound single-stranded DNA followed by strand-specific library construction, Tracking-seq requires a low cell input and is suitable for in vitro, ex vivo and in vivo genome editing, providing a sensitive and practical genome-wide approach for off-target detection in various scenarios. more...

Organism:: Mus musculus; Homo sapiens

Type:: Other; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL24247 GPL24676
111 Samples

Download data: BW

Series

Accession:: GSE236360

ID:: 200236360

PubMed Similar studies

Select item 20026713120.

Comparison of novel proteomic expression profiles for radiation exposure in male and female C57BL6 mice

(Submitter supplied) Purpose: There is a need for point-of-care diagnostics for future mass casualty events involving radiation exposure. The development of radiation exposure and dose prediction algorithms for biodosimetry is needed for screening of large populations during these scenarios, and exploration of the potential effects which sex, age, genetic heterogeneity, and physiological comorbidities may have on the utility of biodosimetry diagnostics is needed. more...

Organism:: Homo sapiens; Mus musculus

Type:: Protein profiling by protein array

Platform:: GPL34462
148 Samples

Download data: TXT

Series

Accession:: GSE267131

ID:: 200267131

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