gal.1[All Fields] AND 1[has_clinical] - GEO DataSets

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Select item 2002026241.

Tumor associated macrophages-programmed core immunosuppressive microenvironments via Galectin-1 in breast cancer

(Submitter supplied) There has been considerable interest in therapeutic targeting of tumor-associated macrophages (TAMs) mainly by depleting or repolarizing them toward anti-tumoral phenotypes. However, a core mediator co-opted for TAMs-mediated remodeling of tumor microenvironment remains poorly understood. Here, to dissect TAMs-mediated early microenvironment, we performed single-cell RNA sequencing of TAMs-enriched and -depleted mouse breast tumor at the early stages of progression, before detectable change in tumor growth appeared. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21273
2 Samples

Download data: ZIP

Series

Accession:: GSE202624

ID:: 200202624

PubMed Full text in PMC Similar studies

Select item 2001540152.

RNA-seq Analysis of mRNA profiles in β-Gal-overexpressing, and HuR-overexpressing primary hepatocytes.

(Submitter supplied) Purpose: The goal of this study is to investigate how HuR regulates hepatocyte death. Methods: mRNA profiles of β-Gal-overexpressing, and HuR-overexpressing primary hepatocytes were generated by deep sequencing using an Illumina Novaseq 6000 platform. Paired-end clean reads were aligned to the mouse reference genome(GRCm38.p6) with Hisat2 v2.0.5, and the aligned reads were used to quantify mRNA expression by using featureCounts v1.5.0-p3. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
6 Samples

Download data: XLSX

Series

Accession:: GSE154015

ID:: 200154015

SRA Run Selector

Select item 2002210373.

Galectin-1-dependent ceRNA network in HRMECs revealed its association with retinal neovascularization

(Submitter supplied) Background: Retinal neovascularization (RNV) is a leading cause of blindness worldwide. Long non-coding RNA (lncRNA) and competing endogenous RNA (ceRNA) regulatory networks play vital roles in angiogenesis. The RNA-binding protein galectin-1 (Gal-1) participates in pathological RNV in oxygen-induced retinopathy mouse models. However, the molecular associations between Gal-1 and lncRNAs remain unclear. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
6 Samples

Download data: TXT

Series

Accession:: GSE221037

ID:: 200221037

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001958134.

RNA-seq of genetically engineered mouse EGFR positive glioblastoma tumors with PDGFRA and GAL-1 positive and negative populations

(Submitter supplied) RNA-seq of genetically engineered mouse EGFR positive glioblastoma tumors flow cytometry sorted into PDGFRA and GAL-1 positive and negative populations.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21626
12 Samples

Download data: CSV

Series

Accession:: GSE195813

ID:: 200195813

PubMed Full text in PMC Similar studies

Select item 2001651635.

TrAEL-seq for CUP1 locus

(Submitter supplied) 1) The Pgal-3HA cup1 yeast strain, in which all CUP1 ORFs are replaced with 3HA and all CUP1 promoters are replaced by GAL1-10 promoters (PMID: 28654659, which carries ~17 tandem repeats of the modified Pgal-3HA cup1 repeat) undergoes extensive CNV when shifted to galactose. Here we use TrAEL-seq to look for replication fork stalling in this strain with and without induction. 2) We also profile the impact on replication of integrating an ARSH4 origin upstream of the RSC30 gene (so outside the CUP1 locus), using the 3xCUP1 strain which carries 3 repeats of CUP1 (PMID: 28654659). more...

Organism:: Saccharomyces cerevisiae

Type:: Other

Platform:: GPL19756
22 Samples

Download data: TXT

Series

Accession:: GSE165163

ID:: 200165163

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001131596.

Effects of high sugar diet on gene expression in the Drosophila labellum

(Submitter supplied) Driven by findings that exposure to a high sugar diet reduced taste sensation in Drosophila, we performed RNA-seq on isolated proboscis tissue from animals that had either received a sugar diet or a control diet. Subsequently, we also profiled expression of animals expressing an RNAi construct to knock down OGT transcript levels in Gr5a+ neurons.

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL22106 GPL17275
13 Samples

Download data: CSV, TSV

Series

Accession:: GSE113159

ID:: 200113159

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000852547.

Galectin-3 Induces a Pro-degradative/inflammatory Gene Signature in Human Chondrocytes, Teaming Up with Galectin-1 in Osteoarthritis Pathogenesis

(Submitter supplied) Inflammatory chemo- and cytokines and matrix-degrading proteases underlie the progression of osteoarthritis (OA). Aiming to define upstream regulators for these disease markers, we pursued initial evidence for an upregulation of members of the adhesion/growth-regulatory galectin family. Immunohistochemical localization of galectin-3 (Gal-3) in sections of human cartilage with increasing levels of degeneration revealed a linear correlation reaching a chondrocyte positivity of 60%. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL15207
8 Samples

Download data: CEL

Series

Accession:: GSE85254

ID:: 200085254

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000751018.

Galectin-1 suppression delineates a new therapeutic strategy for myeloma-induced angiogenesis

(Submitter supplied) Galectin-1 (Gal-1) is a lectin, involved in several processes related to cancer, including immunosuppression, angiogenesis, hypoxia, and metastases. Actually, the Gal-1 expression profile in multiple myeloma (MM) and its pathophysiological role in MM–induced angiogenesis and tumoral growth is unknown. Firstly, we found that Gal-1 was expressed by malignant plasma cells in MM patients and that its expression was up-regulated upon hypoxic treatment (1% of O2). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL15445
6 Samples

Download data: CEL

Series

Accession:: GSE75101

ID:: 200075101

Select item 2000687609.

Galectin-1 couples glycobiology to inflammation in osteoarthritis through the activation of an NF-κB-regulated gene network

(Submitter supplied) Osteoarthritis is a degenerative joint disease that ranks among the leading causes of pain, adult disability, shortening of working life, and socioeconomic costs worldwide. The mechanisms underlying osteoarthritis pathogenesis are yet to be fully elucidated, thus limiting current disease management and treatment. Galectin-1 is an endogenous carbohydrate-binding protein central to adhesion via glycan-bridging, glycoconjugate-mediated signaling, cell proliferation, differentiation, apoptosis, cancers, and host-pathogen interactions. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL15207
10 Samples

Download data: CEL

Series

Accession:: GSE68760

ID:: 200068760

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004899310.

Effects of Diet on Resource Utilization by a Model Human Gut Microbiota Containing Bacteroides cellulosilyticus WH2, a Symbiont with an Extensive Glycobiome (RNA-Seq)

(Submitter supplied) The human gut microbiota is an important metabolic organ, yet little is known about how its individual species interact, establish dominant positions, and respond to changes in environmental factors such as diet. In this study, gnotobiotic mice were colonized with an artificial microbiota comprising 12 sequenced human gut bacterial species and fed oscillating diets of disparate composition. Rapid, reproducible, and reversible changes in the structure of this assemblage were observed. more...

Organism:: Bacteria; Bacteroides cellulosilyticus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL17330 GPL17468
116 Samples

Download data: TXT

Series

Accession:: GSE48993

ID:: 200048993

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20004853711.

Effects of Diet on Resource Utilization by a Model Human Gut Microbiota Containing Bacteroides cellulosilyticus WH2, a Symbiont with an Extensive Glycobiome

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Dorea longicatena DSM 13814; [Clostridium] scindens ATCC 35704; Faecalibacterium prausnitzii M21/2; Collinsella aerofaciens ATCC 25986; Thomasclavelia spiroformis DSM 1552; Bacteria; Bacteroides ovatus ATCC 8483; Bacteroides uniformis ATCC 8492; Phocaeicola vulgatus ATCC 8482; Parabacteroides distasonis ATCC 8503; Bacteroides cellulosilyticus; Bacteroides sp. WH2; Bacteroides thetaiotaomicron VPI-5482; Blautia obeum ATCC 29174; [Ruminococcus] torques ATCC 27756; Bacteroides caccae ATCC 43185; Agathobacter rectalis ATCC 33656

Type:: Expression profiling by high throughput sequencing; Other; Expression profiling by array

5 related Platforms
895 Samples

Download data: CEL, CHP, TXT

Series

Accession:: GSE48537

ID:: 200048537

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004021912.

The galactose regulator GalX regulates the D-galactose oxido-reductive pathway in Aspergillus niger.

(Submitter supplied) Galactose catabolism in Aspergillus nidulans is regulated by at least two regulators, GalR and GalX. In Aspergillus niger only GalX is present, and its role in D-galactose catabolism in this fungus was investigated. Phenotypic and gene expression analysis of a wild type and a galX disruptant revealed that GalX does not substitute for the absence of GalR in A. niger, it regulates the D-galactose oxido-reductive pathway, but not the Leloir pathway. more...

Organism:: Aspergillus niger; Aspergillus niger CBS 513.88

Type:: Expression profiling by array

Platform:: GPL6758
4 Samples

Download data: CEL

Series

Accession:: GSE40219

ID:: 200040219

Select item 20001489813.

Endothelial transcriptomic responses in a mouse model of type II diabetes

(Submitter supplied) Aortic endothelia from mice exposed to dietary model of type II diabetes at 4, 6 and 8 weeks of exposure to Bio-Serv #S3282 diet. Objective: Type II diabetes is associated with endothelial dysfunction, which can contribute to accelerated atherosclerosis and subsequent cardiovascular events. We seek to identify transcripts dysregulated in vivo in response to chronic exposure to high dietary fat that leads to diabetes. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL8203
8 Samples

Download data: GPR

Series

Accession:: GSE14898

ID:: 200014898

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000255414.

Activation of murine CD4+ and CD8+ T lymphocytes leads to dramatic remodeling of N-linked glycans

(Submitter supplied) Activation of murine CD4+ and CD8+ T lymphocytes leads to dramatic remodeling of N-linked glycans. Naïve and activated CD4 T cells, CD8 T cells and B cells were compared for their N-linked glycan structures by MALDI-TOF MS profiling and for expression of glycan transferase genes to assess the biosynthetic basis for any change observed. The major change observed in activated CD4 and CD8 T cells was dramatic reduction of sialylated bi-antennary N-glycans carrying the terminal NeuGc?2-6Gal sequence, and corresponding increase in glycans carrying the Gal?1-3Gal sequence. more...