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Items: 1 to 20 of 62545

1.

P53 terminates the regenerative state after colitis-associated injury

(Submitter supplied) Cell clones that lack P53 signaling occur frequently in ulcerative colitis (UC) and are considered drivers in UC-associated colorectal cancer. Trp53 mutant cells often display decreased P53 signaling and have previously been shown to outcompete wild type (WT) cells in a mouse model of colitis (DSS colitis), but not in healthy mice. However, the mechanism responsible for the observed context-dependent effects of P53 are not understood. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL21163
10 Samples
Download data: TXT
Series
Accession:
GSE254312
ID:
200254312
2.

To elucidate the role of Protein Kinase C in Urothelial Bladder Carcinoma.

(Submitter supplied) Comprehensive evaluation of human cell lines for the transcription dynamics in response to the inhibition of PKC isozymes ε & ζ in bladder cancer.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL21185
24 Samples
Download data: TXT
Series
Accession:
GSE245118
ID:
200245118
3.

Dose-dependent changes in gonadal white adipose tissue in TCDD-elicited steatohepatitis

(Submitter supplied) Bulk RNA-sequencing of 27 C57BL/6 gonadal white adipose tissue samples where ovariectomized females were gavaged 4 days for 92 days with 0.01 to 30 µg/kg TCDD or sesame oil vehicle (n = 3) per dose.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
27 Samples
Download data: TXT
Series
Accession:
GSE272683
ID:
200272683
4.

YTHDF1 loss in dendritic cells potentiates radiationinduced antitumor immunity via STING-dependent type I IFN production

(Submitter supplied) The RNA N6-methyladenosine (m6A) reader YTHDF1 is implicated in cancer etiology and progression. We discovered that radiotherapy (RT) increased YTHDF1 expression in dendritic cells (DCs) of PBMCs from patients with cancer, but not in other immune cells tested. Elevated YTHDF1 expression in DCs was associated with poor outcomes for patients receiving RT. We found that loss of Ythdf1 in DCs enhanced the antitumor effects of ionizing radiation (IR) by increasing the cross-priming capacity of DCs across multiple murine cancer models. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL34328
6 Samples
Download data: TXT
Series
Accession:
GSE272204
ID:
200272204
5.

The interactions among Tumor-infiltrating T lymphocytes (TILS) induced by Stellera chamaejasme and anti-PD-1 therapy with Sing-cell Expression Profiling

(Submitter supplied) Tumor-infiltrating T lymphocytes (TILS) plays a pivotal role in immunotherapy, but the dynamic relationships of the T cells reacted on the therapy remains elusive. T cell receptor (TCR) repertoire, serving as lineage tags, could track these tumor-infiltrating T lymphocytes. Here, in order to deconvolve TILS heterogeneity after therapy in a comprehensive catalog, we presented single T-cell analysis by RNA-seq and TCR tracking of a 22,590 T cells from colorectal carcinoma under control conditions and during Stellera chamaejasme and anti-PD-1 activation. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
10 Samples
Download data: CSV, MTX, TSV
Series
Accession:
GSE186854
ID:
200186854
6.

Somatic mtDNA Mutation Burden Shapes Metabolic Plasticity in Leukemogenesis

(Submitter supplied) The role of somatic mitochondrial DNA (mtDNA) mutations in leukemogenesis remains poorly characterized. To determine the impact of somatic mtDNA mutations on the process, we assessed the leukemogenic potential of hematopoietic progenitor cells (HPCs) from mtDNA mutator mice (Polg D257A) with or without NMyc overexpression. We observed a higher incidence of spontaneous leukemogenesis in recipients transplanted with heterozygous Polg HPCs and a lower incidence of NMyc-driven leukemia in those with homozygous Polg HPCs compared to controls. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL23038
14 Samples
Download data: CEL
Series
Accession:
GSE278440
ID:
200278440
7.

Inhibition of EZH2 restores normal expression of genes associated with cysteine metabolism and ferroptosis in hepatocellular carcinoma [CUT&Tag]

(Submitter supplied) Epigenetic dysregulation is closely associated with the pathogenesis of hepatocellular carcinoma (HCC). Enhancer of zeste homolog 2 (EZH2) is a key protein involved in the exacerbation of various cancers, including HCC. Despite several clinical trials of epigenetic therapies targeting EZH2, the mechanisms underlying EZH2-mediated gene suppression in HCC are not fully understood. In this study, we investigated EZH2-mediated transcriptional programs under EZH2-selective inhibition through an integrative analysis of epigenomic (ATAC-seq) and transcriptomic (RNA-seq) approaches. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL24676
12 Samples
Download data: BIGWIG, TXT
Series
Accession:
GSE268195
ID:
200268195
8.

Inhibition of EZH2 restores normal expression of genes associated with cysteine metabolism and ferroptosis in hepatocellular carcinoma [RNA-seq]

(Submitter supplied) Epigenetic dysregulation is closely associated with the pathogenesis of hepatocellular carcinoma (HCC). Enhancer of zeste homolog 2 (EZH2) is a key protein involved in the exacerbation of various cancers, including HCC. Despite several clinical trials of epigenetic therapies targeting EZH2, the mechanisms underlying EZH2-mediated gene suppression in HCC are not fully understood. In this study, we investigated EZH2-mediated transcriptional programs under EZH2-selective inhibition through an integrative analysis of epigenomic (ATAC-seq) and transcriptomic (RNA-seq) approaches. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
8 Samples
Download data: TXT
Series
Accession:
GSE237951
ID:
200237951
9.

Evaluation of transcriptomic changes in a Neuro2a cell line under extreme stress

(Submitter supplied) Bulk poly(A) RNA-sequencing was performed to evaluate the transcriptomic profiles of Neuro2a cells exposed to extreme stress following thawing in liquid N2 storage. This RNA-seq experiment was conducted as a part of broader aim in our study to evaluate changes gene expression of stressed cells in the early stages of recovery at Passage 1 post-thaw (P1) and as cells progressed towards a healthy phenotype at Passage 6 post-thaw (P6). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
13 Samples
Download data: TXT
Series
Accession:
GSE264224
ID:
200264224
10.

Gene expression data from THP-1 cells infected with different Mycobacterium tuberculosis strains

(Submitter supplied) Host-pathogen interactions in Mycobacterium tuberculosis infection still remain poorly understood. We investigated the host immune response to different reference Mycobacterium tuberculosis strains in THP-1 cells. Major differences in the gene expression profiles were identified in response to infection with these strains. These findings shed new insights into the dynamic variation in tuberculosis immune response and pathogenesis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5175
30 Samples
Download data: CEL
Series
Accession:
GSE246736
ID:
200246736
11.

Integration of epigenomic and transcriptomic profiling uncovers EZH2 target genes linked to cysteine metabolism in hepatocellular carcinoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL24676 GPL16791
24 Samples
Download data: BIGWIG, TXT
Series
Accession:
GSE237952
ID:
200237952
12.

Bulk RNA-sequencing of kidneys from male C57BL/6 mice subacutely exposed to TCDD.

(Submitter supplied) Bulk RNA-sequencing of 40 C57BL/6NCrl mouse-right kidney samples where males were gavaged every 4 days for 28 days with 0.03 to 30 µg/kg TCDD or sesame oil vehicle (n=5 per dose). Gavaging and tissue collection occurred between ZT0-3.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
40 Samples
Download data: TAB, TXT
Series
Accession:
GSE272652
ID:
200272652
13.

Porphyromonas gingivalis triggers microglia activation and neurodegenerative processes through NOX4

(Submitter supplied) Periodontitis and infections with periodontal bacteria have been highlighted as risk factors for dementia. In recent years attention has been drawn to the role of microglia cells in neurodegenerative diseases. However, there is limited knowledge of the influence of periodontal bacteria on microglia cells. The aim of the present study was to investigate the interactions between the periodontal bacteria P. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL21185
16 Samples
Download data: TXT
Series
Accession:
GSE274532
ID:
200274532
14.

Interferon epsilon as a novel anti-viral agent in the testis [human]

(Submitter supplied) The testis is susceptible to viral infections, which can impair fertility. Spermatogenic cells were thought to lack anti-viral defences, including interferon (IFN) or IFN-stimulated gene (ISG) expression. Challenging this dogma, we discovered that interferon-epsilon (IFNɛ), a type-I IFN first identified in female reproductive epithelia, is constitutively expressed by spermatogenic cells and macrophages in mouse and human testes. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL30173
48 Samples
Download data: CSV
Series
Accession:
GSE252991
ID:
200252991
15.

Impaired p53-Mediated DNA Damage Response Contributes to Microcephaly in Nijmegen Breakage Syndrome Patient-Derived Cerebral Organoids

(Submitter supplied) Nijmegen Breakage Syndrome (NBS) is a rare autosomal recessive genetic disorder caused by mutations within nibrin (NBN), a DNA damage repair protein. Hallmarks of NBS include chromosomal instability and clinical manifestations such as growth retardation, immunodeficiency, and progressive microcephaly. We employed induced pluripotent stem cell-derived cerebral organoids from two NBS patients to study the etiology of microcephaly. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL23159
11 Samples
Download data: CEL
Series
Accession:
GSE279611
ID:
200279611
16.

Gene expression profile in JAR (HTB-144, ATCC) cells with scrambled control or miR-34a mimic transfection

(Submitter supplied) We examined gene expression variations in JAR cells between scrambled control and miR-34a mimic transfection
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL23159
5 Samples
Download data: CEL, CHP
Series
Accession:
GSE279257
ID:
200279257
17.

Interplay between nutrient stress and lysosomal signaling imprints immune memory in tissues [microarray3]

(Submitter supplied) Uncovered organelle signaling and metabolic processes shaping CD8+ tissue-resident memory (TRM) development
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL23038
24 Samples
Download data: CEL, TXT
Series
Accession:
GSE231500
ID:
200231500
18.

Interplay between nutrient stress and lysosomal signaling imprints immune memory in tissues [microarray2]

(Submitter supplied) Uncovered organelle signaling and metabolic processes shaping CD8+ tissue-resident memory (TRM) development
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL23038
22 Samples
Download data: CEL, TXT, ZIP
Series
Accession:
GSE231499
ID:
200231499
19.

Interplay between nutrient stress and lysosomal signaling imprints immune memory in tissues [microarray1]

(Submitter supplied) Uncovered organelle signaling and metabolic processes shaping CD8+ tissue-resident memory (TRM) development
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL23038
20 Samples
Download data: CEL, TXT
Series
Accession:
GSE231498
ID:
200231498
20.

Interplay between nutrient stress and lysosomal signaling imprints immune memory in tissues [microarray4]

(Submitter supplied) Uncovered organelle signaling and metabolic processes shaping CD8+ tissue-resident memory (TRM) development
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL23038
14 Samples
Download data: CEL, TXT
Series
Accession:
GSE231342
ID:
200231342
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