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Select item 2002543121.

P53 terminates the regenerative state after colitis-associated injury

(Submitter supplied) Cell clones that lack P53 signaling occur frequently in ulcerative colitis (UC) and are considered drivers in UC-associated colorectal cancer. Trp53 mutant cells often display decreased P53 signaling and have previously been shown to outcompete wild type (WT) cells in a mouse model of colitis (DSS colitis), but not in healthy mice. However, the mechanism responsible for the observed context-dependent effects of P53 are not understood. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL21163
10 Samples

Download data: TXT

Series

Accession:: GSE254312

ID:: 200254312

Select item 2002451182.

To elucidate the role of Protein Kinase C in Urothelial Bladder Carcinoma.

(Submitter supplied) Comprehensive evaluation of human cell lines for the transcription dynamics in response to the inhibition of PKC isozymes ε & ζ in bladder cancer.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL21185
24 Samples

Download data: TXT

Series

Accession:: GSE245118

ID:: 200245118

Select item 2002726833.

Dose-dependent changes in gonadal white adipose tissue in TCDD-elicited steatohepatitis

(Submitter supplied) Bulk RNA-sequencing of 27 C57BL/6 gonadal white adipose tissue samples where ovariectomized females were gavaged 4 days for 92 days with 0.01 to 30 µg/kg TCDD or sesame oil vehicle (n = 3) per dose.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
27 Samples

Download data: TXT

Series

Accession:: GSE272683

ID:: 200272683

Select item 2002722044.

YTHDF1 loss in dendritic cells potentiates radiationinduced antitumor immunity via STING-dependent type I IFN production

(Submitter supplied) The RNA N6-methyladenosine (m6A) reader YTHDF1 is implicated in cancer etiology and progression. We discovered that radiotherapy (RT) increased YTHDF1 expression in dendritic cells (DCs) of PBMCs from patients with cancer, but not in other immune cells tested. Elevated YTHDF1 expression in DCs was associated with poor outcomes for patients receiving RT. We found that loss of Ythdf1 in DCs enhanced the antitumor effects of ionizing radiation (IR) by increasing the cross-priming capacity of DCs across multiple murine cancer models. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL34328
6 Samples

Download data: TXT

Series

Accession:: GSE272204

ID:: 200272204

Select item 2001868545.

The interactions among Tumor-infiltrating T lymphocytes (TILS) induced by Stellera chamaejasme and anti-PD-1 therapy with Sing-cell Expression Profiling

(Submitter supplied) Tumor-infiltrating T lymphocytes (TILS) plays a pivotal role in immunotherapy, but the dynamic relationships of the T cells reacted on the therapy remains elusive. T cell receptor (TCR) repertoire, serving as lineage tags, could track these tumor-infiltrating T lymphocytes. Here, in order to deconvolve TILS heterogeneity after therapy in a comprehensive catalog, we presented single T-cell analysis by RNA-seq and TCR tracking of a 22,590 T cells from colorectal carcinoma under control conditions and during Stellera chamaejasme and anti-PD-1 activation. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
10 Samples

Download data: CSV, MTX, TSV

Series

Accession:: GSE186854

ID:: 200186854

SRA Run Selector

Select item 2002784406.

Somatic mtDNA Mutation Burden Shapes Metabolic Plasticity in Leukemogenesis

(Submitter supplied) The role of somatic mitochondrial DNA (mtDNA) mutations in leukemogenesis remains poorly characterized. To determine the impact of somatic mtDNA mutations on the process, we assessed the leukemogenic potential of hematopoietic progenitor cells (HPCs) from mtDNA mutator mice (Polg D257A) with or without NMyc overexpression. We observed a higher incidence of spontaneous leukemogenesis in recipients transplanted with heterozygous Polg HPCs and a lower incidence of NMyc-driven leukemia in those with homozygous Polg HPCs compared to controls. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL23038
14 Samples

Download data: CEL

Series

Accession:: GSE278440

ID:: 200278440

Analyze with GEO2R

Select item 2002681957.

Inhibition of EZH2 restores normal expression of genes associated with cysteine metabolism and ferroptosis in hepatocellular carcinoma [CUT&Tag]

(Submitter supplied) Epigenetic dysregulation is closely associated with the pathogenesis of hepatocellular carcinoma (HCC). Enhancer of zeste homolog 2 (EZH2) is a key protein involved in the exacerbation of various cancers, including HCC. Despite several clinical trials of epigenetic therapies targeting EZH2, the mechanisms underlying EZH2-mediated gene suppression in HCC are not fully understood. In this study, we investigated EZH2-mediated transcriptional programs under EZH2-selective inhibition through an integrative analysis of epigenomic (ATAC-seq) and transcriptomic (RNA-seq) approaches. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24676
12 Samples

Download data: BIGWIG, TXT

Series

Accession:: GSE268195

ID:: 200268195

Select item 2002379518.

Inhibition of EZH2 restores normal expression of genes associated with cysteine metabolism and ferroptosis in hepatocellular carcinoma [RNA-seq]

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
8 Samples

Download data: TXT

Series

Accession:: GSE237951

ID:: 200237951

Select item 2002642249.

Evaluation of transcriptomic changes in a Neuro2a cell line under extreme stress

(Submitter supplied) Bulk poly(A) RNA-sequencing was performed to evaluate the transcriptomic profiles of Neuro2a cells exposed to extreme stress following thawing in liquid N2 storage. This RNA-seq experiment was conducted as a part of broader aim in our study to evaluate changes gene expression of stressed cells in the early stages of recovery at Passage 1 post-thaw (P1) and as cells progressed towards a healthy phenotype at Passage 6 post-thaw (P6). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
13 Samples

Download data: TXT

Series

Accession:: GSE264224

ID:: 200264224

PubMed Similar studies

Select item 20024673610.

Gene expression data from THP-1 cells infected with different Mycobacterium tuberculosis strains

(Submitter supplied) Host-pathogen interactions in Mycobacterium tuberculosis infection still remain poorly understood. We investigated the host immune response to different reference Mycobacterium tuberculosis strains in THP-1 cells. Major differences in the gene expression profiles were identified in response to infection with these strains. These findings shed new insights into the dynamic variation in tuberculosis immune response and pathogenesis. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5175
30 Samples

Download data: CEL

Series

Accession:: GSE246736

ID:: 200246736

Analyze with GEO2R

Select item 20023795211.

Integration of epigenomic and transcriptomic profiling uncovers EZH2 target genes linked to cysteine metabolism in hepatocellular carcinoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL24676 GPL16791
24 Samples

Download data: BIGWIG, TXT

Series

Accession:: GSE237952

ID:: 200237952

Select item 20027265212.

Bulk RNA-sequencing of kidneys from male C57BL/6 mice subacutely exposed to TCDD.

(Submitter supplied) Bulk RNA-sequencing of 40 C57BL/6NCrl mouse-right kidney samples where males were gavaged every 4 days for 28 days with 0.03 to 30 µg/kg TCDD or sesame oil vehicle (n=5 per dose). Gavaging and tissue collection occurred between ZT0-3.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
40 Samples

Download data: TAB, TXT

Series

Accession:: GSE272652

ID:: 200272652

Select item 20027453213.

Porphyromonas gingivalis triggers microglia activation and neurodegenerative processes through NOX4

(Submitter supplied) Periodontitis and infections with periodontal bacteria have been highlighted as risk factors for dementia. In recent years attention has been drawn to the role of microglia cells in neurodegenerative diseases. However, there is limited knowledge of the influence of periodontal bacteria on microglia cells. The aim of the present study was to investigate the interactions between the periodontal bacteria P. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL21185
16 Samples

Download data: TXT

Series

Accession:: GSE274532

ID:: 200274532

Analyze with GEO2R

Select item 20025299114.

Interferon epsilon as a novel anti-viral agent in the testis [human]

(Submitter supplied) The testis is susceptible to viral infections, which can impair fertility. Spermatogenic cells were thought to lack anti-viral defences, including interferon (IFN) or IFN-stimulated gene (ISG) expression. Challenging this dogma, we discovered that interferon-epsilon (IFNɛ), a type-I IFN first identified in female reproductive epithelia, is constitutively expressed by spermatogenic cells and macrophages in mouse and human testes. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30173
48 Samples

Download data: CSV

Series

Accession:: GSE252991

ID:: 200252991

Select item 20027961115.

Impaired p53-Mediated DNA Damage Response Contributes to Microcephaly in Nijmegen Breakage Syndrome Patient-Derived Cerebral Organoids

(Submitter supplied) Nijmegen Breakage Syndrome (NBS) is a rare autosomal recessive genetic disorder caused by mutations within nibrin (NBN), a DNA damage repair protein. Hallmarks of NBS include chromosomal instability and clinical manifestations such as growth retardation, immunodeficiency, and progressive microcephaly. We employed induced pluripotent stem cell-derived cerebral organoids from two NBS patients to study the etiology of microcephaly. more...