caspase-activated DNase - GEO DataSets

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Items: 2

Select item 2001554931.

The Caspase-Activated DNAse drives chromosomal instability and cancer metastasis

(Submitter supplied) Chromosome-segregation errors in cancer cells are linked to chromosomal instability, the appearance of micronuclei and subsequent intracellular signaling events that drive cancer metastasis. The cause of these aberrations is not well-defined but a link to DNA-damage has been established. The Caspase-Activated DNAse (CAD) has been discovered for its role in the degradation of DNA in apoptotic cells but can also be activated in the absence of cell death. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
23 Samples

Download data: TXT

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Accession:: GSE155493

ID:: 200155493

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001712422.

Cancer cells utilize self-inflicted DNA breaks to evade growth limits imposed by exogenous genotoxic stress

(Submitter supplied) Exposure to genotoxic challenge activates cell cycle checkpoints to prevent progression and propagation of deleterious DNA damage. We identify the activity of a nuclease, Caspase-activated DNase (CAD), in promoting G2 checkpoint control in cancer cells via the infliction of DNA breaks. To appreciate the genomic context of these breaks, we performed (genome wide ligation of 3’-hydroxy (OH) ends followed by sequencing), to map the endogenously inflicted DNA breaks following irradiation.