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Items: 5

1.

Genetic inhibition of CARD9 accelerates the development of experimental atherosclerosis through CD36 dependent-defective autophagy

(Submitter supplied) Macrophage-mediated innate immune responses contribute to the initiation, progression and complications of atherosclerosis. However, the underlying pathways linking activation of macrophages to atherosclerotic plaque develoment are still poorly understood. We hypothesized that activation of caspase recruitment-domain containing protein 9 (CARD9) plays a determinant role in pro-atherogenic responses in macrophages. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
8 Samples
Download data: CSV
Series
Accession:
GSE221782
ID:
200221782
2.

Apoptosis-associated speck-like protein containing a CARD regulates the growth of pancreatic ductal adenocarcinoma

(Submitter supplied) Apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) is a key adaptor protein of inflammasomes but also a proapoptotic molecule. We clarified the role and mechanisms of ASC in vitro data based on PDAC cells. ASC expression in PDAC cells was downregulated using small-interfering (si)RNA, and gene expression was assessed by RNA sequencing. PDAC cells were further analyzed using a proliferation assay and cell cycle analysis. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL15520
9 Samples
Download data: TXT
3.

Cecum gene expression signatures in germ-free WT mice colonized with microbiota from WT or Card9-/- mice and infected with Citrobacter rodentium induced colitis

(Submitter supplied) It is crucial to decipher the host-microbiota interactions as they are involved in intestinal homeostasis and diseases. Caspase Recruitment Domain 9 (Card9) is an inflammatory bowel disease (IBD) susceptibility gene coding for an adapter protein for innate immunity toward many microorganisms. Card9-/- mice are more susceptible to colitis induced by Citrobacter rodentium as a result of impaired of the IL-22 pathway. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10787
40 Samples
Download data: TXT
Series
Accession:
GSE90577
ID:
200090577
4.

ASC deficiency suppresses proliferation and prevents medulloblastoma incidence

(Submitter supplied) Apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) is silenced by promoter methylation in many types of tumors, yet ASC's role in most cancers remains unknown. Here, we show that ASC is highly expressed in a model of medulloblastoma, the most common malignant pediatric brain cancer; ASC is also expressed in human medulloblastomas. Importantly, while ASC deficiency did not affect normal cerebellar development, ASC knockout mice on the Smoothened (ND2:SmoA1) transgenic model of medulloblastoma exhibited a profound reduction in medulloblastoma incidence and a delayed tumor onset. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL4134
9 Samples
Download data
Series
Accession:
GSE48682
ID:
200048682
5.

The Genetic Regulation of the Terminating Phase of Liver Regeneration

(Submitter supplied) The liver regeneration process terminates when the normal liver-mass/body-weight ratio of 2.5 % has been re-established. We aimed to generate and analyse global expression profiles to study the genetic interactions in relation to liver regeneration, to illuminate the genetic interactions between genes regulating the cell cycle and apoptosis, and to clarify the role of TGF-ß signalling in the terminating phase of liver regeneration. more...
Organism:
Sus scrofa
Type:
Expression profiling by array
Platform:
GPL5972
35 Samples
Download data: GPR
Series
Accession:
GSE14396
ID:
200014396
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