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Items: 6

  • Unknown field was ignored: [has_clinical].
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1.

Modeling Braf-induced thyroid cancer development and cell redifferentiation using pluripotent stem cell-derived organoids

(Submitter supplied) To generate a papillary thyroid carcinoma organoid model by inducing the BrafV637E mutation in mouse embryonic stem cells derived functional thyroid follicles to better comprehend the oncogenic events driven by Braf-oncogene and develop a drug screening tool. We performed gene expression profiling analysis using data obtained from bulk RNA-seq of organoid model with and without induction of BrafV637E expression induction, after MEK and PI3K inhibitors addition).
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
6 Samples
Download data: TXT
Series
Accession:
GSE228281
ID:
200228281
2.

Liver ILC2s suppress gluconeogenesis and limit blood glucose elevation through IL-13 signaling

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL24247 GPL19057 GPL18480
30 Samples
Download data: BEDGRAPH, TAR
Series
Accession:
GSE189287
ID:
200189287
3.

Liver ILC2s suppress gluconeogenesis and limit blood glucose elevation through IL-13 signaling [bulkRNA-seq_Hepatocyte]

(Submitter supplied) The liver stores glycogen and releases blood glucose and is therefore essential for glucose metabolism. Group 2 innate lymphoid cells (ILC2s) in adipose and pancreatic tissues are involved in glucose homeostasis, but the metabolic contribution of liver ILC2s remains unclear. Herein, we show that interleukin (IL)-33 treatment induced IL-13 production in liver ILC2s, which consequently reduced blood glucose levels. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18480
15 Samples
Download data: BEDGRAPH, XLSX
Series
Accession:
GSE189282
ID:
200189282
4.

Defining a role for GPCR/cAMP/Creb signaling in HFSC activation

(Submitter supplied) Our study demonstrates direct evidence that canonical cAMP/Creb signaling through adrenergic receptors can regulate HFSC activation and the hair cycle. This intracellular signaling circuit connects to downstrean glycolytic metabolism processes which have been previously shown to stimulate HSFC activation.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
5 Samples
Download data: TXT
Series
Accession:
GSE173591
ID:
200173591
5.

BRAF organoid, D31, cAMP, rep1

Organism:
Mus musculus
Source name:
organoid
Platform:
GPL24247
Series:
GSE228281
Download data
Sample
Accession:
GSM7118171
ID:
307118171
6.

cAMP1 cyclicAMP1

Organism:
Mus musculus
Source name:
Total epidermis
Platform:
GPL21493
Series:
GSE173591
Download data
Sample
Accession:
GSM5271499
ID:
305271499
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Supplemental Content

db=gds|term=camp1[All%20Fields]%20AND%201[has_clinical]|query=5|qty=2|blobid=MCID_6728320e9f58a261472f1d6f|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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