Framework humanization increases the affinity and potency of anti-CD72 nanobody-based CAR-T cells for B-cell malignancies - - GEO DataSets

Summary

Format

Summary
Summary (text)
Unique Identifier List

Send to:

Choose Destination

File
Clipboard
Collections

Showing results for steri discover. Your search for Stelis discolor retrieved no results.

Framework humanization increases the affinity and potency of anti-CD72 nanobody-based CAR-T cells for B-cell malignancies

(Submitter supplied) Anti-CD19 CAR T cells can induce remissions in some patients with B-cell malignancies. However, new immunotherapeutic targets are urgently needed for the many who relapse. We recently described CD72 as a promising target in B-cell leukemia and lymphoma, developing fully synthetic nanobody-based CAR-T cells (nanoCARs) against this antigen. Toward clinical translation, here we humanize our previous nanobody framework regions, derived from llama, and surprisingly discover a clone ("H24") with enhanced potency against B-cell tumors both in vitro and in vivo. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23227
18 Samples

Download data: TSV

Series

Accession:: GSE218791

ID:: 200218791

PubMed Full text in PMC Similar studies Analyze with GEO2R

Supplemental Content

Related information

PubMed
Related PubMed entries
Full text in PMC
PMC links
Similar studies
Similar studies
BioProject
BioProject links
Taxonomy
Taxonomy

Search details

Important Links

Recent activity

Clear Turn Off Turn On

Framework humanization increases the affinity and potency of anti-CD72 nanobody-...
Framework humanization increases the affinity and potency of anti-CD72 nanobody-based CAR-T cells for B-cell malignancies
Accession: GSE218791

GEO DataSets
steri discover (1)
GEO DataSets
type IV secretion system protein [Bartonella henselae]
type IV secretion system protein [Bartonella henselae]
gi|2184163969|ref|WP_236095417.1|

Protein
Tortula muralis var. muralis voucher Kosnar-1033 clone 1 18S ribosomal RNA gene,...
Tortula muralis var. muralis voucher Kosnar-1033 clone 1 18S ribosomal RNA gene, partial sequence; internal transcribed spacer 1, 5.8S ribosomal RNA gene, and internal transcribed spacer 2, complete sequence; and 26S ribosomal RNA gene, partial sequence
gi|353336133|gb|JN544792.1|

Nucleotide
Chain B, NEDD8-activating enzyme E1 catalytic subunit
Chain B, NEDD8-activating enzyme E1 catalytic subunit
gi|285803224|pdb|3GZN|B

Protein

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on