Senecionine - GEO DataSets - NCBI

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Select item 2001661951.

Gene expression changes in rat lung induced by six pyrrolizidine alkaloids

(Submitter supplied) Pyrrolizidine alkaloids (PAs) are secondary plant metabolites that can be found worldwide. They can have an impact to human health by inducing acute toxic effects like veno-occlusive disease in the liver and pulmonary arterial hypertension in the lung. The study focuses on the identification of gene expression changes in vivo in rat lungs after treatment with six structurally different PAs (echimidine, heliotrine, lasiocarpine, senecionine, senkirkine or platyphylline). more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL23040
48 Samples

Download data: CEL

Series

Accession:: GSE166195

ID:: 200166195

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001496782.

Gene expression changes in rat liver induced by 6 PA

(Submitter supplied) Pyrrolizidine alkaloids (PA) are secondary plant metabolites that occur as food and feed contaminants. Acute and subacute PA poisoning can lead to severe liver damage in humans and animals. Chronic exposure to low levels of PA can induce liver cirrhosis and liver cancer. However, it is not well understood which transcriptional changes are induced by PA and whether all hepatotoxic PA, regardless of their structure, induce similar responses. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL22388
110 Samples

Download data: CEL

Series

Accession:: GSE149678

ID:: 200149678

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000692693.

Disturbance of gene expression in primary human hepatocytes by hepatotoxic pyrrolizidine alkaloids: a whole genome transcriptome analysis

(Submitter supplied) 1,2-unsaturated pyrrolizidine alkaloids (PA) are plant metabolites predominantly occurring in the plant families Asteraceae and Boraginaceae. Acute and chronic PA poisoning causes severe hepatotoxicity. So far, the molecular mechanisms of PA toxicity are not well understood. To analyze its mode of action, primary human hepatocytes were exposed to a non-cytotoxic dose of 100 µM of four structurally different PA: echimidine, heliotrine, senecionine, senkirkine. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
15 Samples

Download data: CEL

Series

Accession:: GSE69269

ID:: 200069269

PubMed Similar studies Analyze with GEO2R

Select item 2000441444.

Development of gene expression signatures for senecionine exposure

(Submitter supplied) Senecionine is among the most well-studied pyrrolizidine alkaloids, which have caused intense and lasting attention for their significant hepatotoxicity. To develop gene expression approach to senecionine exposure, we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to be biomarkers after senecionine exposure. Rat liver tissues after 36 h of senecionine treatment (i.g., 35 mg/kg body weight) were collected and analyzed comparing with control samples (i.g., sodium chloride solution). more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL7294
2 Samples

Download data: TXT

Series

Accession:: GSE44144

ID:: 200044144

Analyze with GEO2R

Select item 3050657205.

Kidney, Senecionine 3.3 mg/kg/bw_animal 4

Organism:: Rattus norvegicus

Source name:: mRNA, kidney after 28 days oral treatment

Platform:: GPL23040
Series:: GSE166195

Download data: CEL

Sample

Accession:: GSM5065720

ID:: 305065720

Select item 3050657196.

Kidney, Senecionine 3.3 mg/kg/bw_animal 3

Organism:: Rattus norvegicus

Source name:: mRNA, kidney after 28 days oral treatment

Platform:: GPL23040
Series:: GSE166195

Download data: CEL

Sample

Accession:: GSM5065719

ID:: 305065719

Select item 3050657187.

Kidney, Senecionine 3.3 mg/kg/bw_animal 2

Organism:: Rattus norvegicus

Source name:: mRNA, kidney after 28 days oral treatment

Platform:: GPL23040
Series:: GSE166195

Download data: CEL

Sample

Accession:: GSM5065718

ID:: 305065718

Select item 3050657178.

Kidney, Senecionine 3.3 mg/kg/bw_animal 1

Organism:: Rattus norvegicus

Source name:: mRNA, kidney after 28 days oral treatment

Platform:: GPL23040
Series:: GSE166195

Download data: CEL

Sample

Accession:: GSM5065717

ID:: 305065717

Select item 3050657129.

Lung, Senecionine 0.33 mg/kg/bw_animal 4

Organism:: Rattus norvegicus

Source name:: mRNA, lung after 28 days oral treatment

Platform:: GPL23040
Series:: GSE166195

Download data: CEL

Sample

Accession:: GSM5065712

ID:: 305065712

Select item 30506571110.

Lung, Senecionine 0.33 mg/kg/bw_animal 3

Organism:: Rattus norvegicus

Source name:: mRNA, lung after 28 days oral treatment

Platform:: GPL23040
Series:: GSE166195

Download data: CEL

Sample

Accession:: GSM5065711

ID:: 305065711

Select item 30506571011.

Lung, Senecionine 0.33 mg/kg/bw_animal 2

Organism:: Rattus norvegicus

Source name:: mRNA, lung after 28 days oral treatment

Platform:: GPL23040
Series:: GSE166195

Download data: CEL

Sample

Accession:: GSM5065710

ID:: 305065710

Select item 30506570912.

Lung, Senecionine 0.33 mg/kg/bw_animal 1

Organism:: Rattus norvegicus

Source name:: mRNA, lung after 28 days oral treatment

Platform:: GPL23040
Series:: GSE166195

Download data: CEL

Sample

Accession:: GSM5065709

ID:: 305065709

Select item 30506570813.

Lung, Senecionine 1 mg/kg/bw_animal 4

Organism:: Rattus norvegicus

Source name:: mRNA, lung after 28 days oral treatment

Platform:: GPL23040
Series:: GSE166195

Download data: CEL

Sample

Accession:: GSM5065708

ID:: 305065708

Select item 30506570714.

Lung, Senecionine 1 mg/kg/bw_animal 3

Organism:: Rattus norvegicus

Source name:: mRNA, lung after 28 days oral treatment

Platform:: GPL23040
Series:: GSE166195

Download data: CEL

Sample

Accession:: GSM5065707

ID:: 305065707

Select item 30506570615.

Lung, Senecionine 1 mg/kg/bw_animal 2

Organism:: Rattus norvegicus

Source name:: mRNA, lung after 28 days oral treatment

Platform:: GPL23040
Series:: GSE166195

Download data: CEL

Sample

Accession:: GSM5065706

ID:: 305065706

Select item 30506570516.

Lung, Senecionine 1 mg/kg/bw_animal 1

Organism:: Rattus norvegicus

Source name:: mRNA, lung after 28 days oral treatment

Platform:: GPL23040
Series:: GSE166195

Download data: CEL

Sample

Accession:: GSM5065705

ID:: 305065705

Select item 30506569217.

Lung, Senecionine 3.3 mg/kg/bw_animal 4

Organism:: Rattus norvegicus

Source name:: mRNA, lung after 28 days oral treatment

Platform:: GPL23040
Series:: GSE166195

Download data: CEL

Sample

Accession:: GSM5065692

ID:: 305065692

Select item 30506569118.

Lung, Senecionine 3.3 mg/kg/bw_animal 3

Organism:: Rattus norvegicus

Source name:: mRNA, lung after 28 days oral treatment

Platform:: GPL23040
Series:: GSE166195

Download data: CEL

Sample

Accession:: GSM5065691

ID:: 305065691

Select item 30506569019.

Lung, Senecionine 3.3 mg/kg/bw_animal 2

Organism:: Rattus norvegicus

Source name:: mRNA, lung after 28 days oral treatment

Platform:: GPL23040
Series:: GSE166195

Download data: CEL

Sample

Accession:: GSM5065690

ID:: 305065690

Select item 30506568920.

Lung, Senecionine 3.3 mg/kg/bw_animal 1

Organism:: Rattus norvegicus

Source name:: mRNA, lung after 28 days oral treatment

Platform:: GPL23040
Series:: GSE166195

Download data: CEL

Sample

Accession:: GSM5065689

ID:: 305065689

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