GEO DataSets

(Submitter supplied) The genetic code that specifies the identity of amino acids incorporated into proteins during protein synthesis is almost universally conserved. Mitochondrial translation, however, exhibits deviations from the standard genetic code including reassigning of two arginine codons to stop codons. Translation termination at these non-canonical stop codons requires a protein factor to release the newly synthesized polypeptide chain. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24676

5 Samples

Download data: BW

(Submitter supplied) The genetic code that specifies the identity of amino acids incorporated into proteins during protein synthesis is almost universally conserved. Mitochondrial translation deviates from the standard genetic code which includes the reassignment of two arginine codons into stop codons {Jukes, 1993 #438}. Translation termination at these non-canonical stop codons requires a protein factor to release the newly synthesized polypeptide chain, however, the identity of this factor is not known currently{Nadler, 2021 #406}. more...

Organism:

Homo sapiens

Type:

Other

Platform:

GPL24676

2 Samples

Download data: BEDGRAPH, FA

(Submitter supplied) Programmed ribosomal frameshifting is the key event during translation of the SARS-CoV-2 RNA genome allowing synthesis of the viral RNA-dependent RNA polymerase and downstream viral proteins. Here we present the cryo-EM structure of the mammalian ribosome in the process of translating viral RNA paused in a conformation primed for frameshifting. We observe that the viral RNA adopts a pseudoknot structure lodged at the mRNA entry channel of the ribosome to generate tension in the mRNA that leads to frameshifting. more...

Organism:

Severe acute respiratory syndrome coronavirus 2

Type:

Other

Platform:

GPL29767

4 Samples

Download data: WIG