GEO DataSets

(Submitter supplied) Comparison of mRNA expression showed widespread changes in the circulating CD8+ but not CD4+ T-cells from patients with severe asthma. No changes were observed in the CD4+ and CD8+ T-cells in non-severe asthmatics versus healthy controls. Bioinformatics analysis showed that the changes in CD8+ T-cell mRNA expression were associated with multiple pathways involved in T-cell activation. As with mRNAs, we also observed widespread changes in expression of non-coding RNA species including natural antisense, pseudogenes, intronic long ncRNAs and long intergenic long ncRNAs in CD8+ T-cells from severe asthmatics. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4425

Platform:

GPL570

40 Samples

Download data: CEL

Analysis of circulating CD4+ and CD8+ T-cells from adult patients with severe or nonsevere asthma. CD4+ T cells contribute to the development and maintenance of an inflammatory response in asthmatic patients. Results provide insight into the role of CD8+ T cells in severe asthma.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 cell type, 3 disease state sets

Platform:

GPL570

Series:

GSE31773

40 Samples

Download data: CEL