RAD2 - GEO DataSets

Select item 2001867371.

BCG invokes superior STING-mediated innate immune response over radiotherapy in a carcinogen murine model of urothelial cancer

(Submitter supplied) Radiation and BCG instillations are used clinically for treatment of urothelial carcinoma, but the precise mechanisms by which they activate an immune response remain elusive. The role of the cGAS-STING pathway has been implicated in both BCG and radiation-induced immune response however comparison of STING-pathway molecules and immune landscape following treatment in urothelial carcinoma has not be performed. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL25266
23 Samples

Download data: RCC

Series

Accession:: GSE186737

ID:: 200186737

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001479272.

A high-resolution protein architecture of the budding yeast genome

(Submitter supplied) The genome-wide architecture of chromatin-associated proteins that maintains chromosome integrity and gene regulation is ill defined. Here we use chromatin immunoprecipitation, exonuclease digestion and DNA sequencing (ChIP–exo/seq) to define this architecture in Saccharomyces cerevisiae. We identify 21 meta-assemblages consisting of roughly 400 different proteins that are related to DNA replication, centromeres, subtelomeres, transposons, and transcription by RNA polymerase (Pol) I, II and III. more...

Organism:: Saccharomyces cerevisiae

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL19756
1251 Samples

Download data: BED, BW

Series

Accession:: GSE147927

ID:: 200147927

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001539453.

Persistent activation of mRNA translation by transient Hsp90 inhibition

(Submitter supplied) The heat shock protein 90 (Hsp90) chaperone functions as a protein-folding buffer and plays a unique role promoting the evolution of new heritable traits. To better understand how Hsp90 can affect mRNA translation we screened more than 1600 factors involved in mRNA regulation for physical interactions with Hsp90 in human cells. The mRNA binding protein CPEB2 strongly binds Hsp90 via its prion domain. more...

Organism:: Saccharomyces cerevisiae

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL17342
12 Samples

Download data: TXT

Series

Accession:: GSE153945

ID:: 200153945

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000035744.

A DNA integrity network in the yeast Saccharomyces cerevisiae

(Submitter supplied) A network governing DNA integrity was identified in yeast by a global genetic analysis of synthetic fitness or lethality defect (SFL) interactions. Within this network, multiple functional modules or mini-pathways were defined according to their common patterns of global SFL interactions and available protein-protein interaction information. Modules or genes involved in DNA replication, DNA replication checkpoint signaling, and oxidative stress response were identified as the major guardians against lethal spontaneous DNA damage, efficient repair of which requires the functions of the DNA damage checkpoint signaling and multiple DNA repair pathways. more...

Organism:: Saccharomyces cerevisiae

Type:: Other

Platform:: GPL1444
121 Samples

Download data: TIFF

Series

Accession:: GSE3574

ID:: 200003574

Select item 9685.

Radiation therapy toxicity association with abnormal transcriptional response to DNA damage

Analysis of UV and IR irradiated lymphoblastoid cell lines derived from the peripheral blood of patients with acute radiation toxicity. Samples taken 2 months after the completion of radiation therapy. Results provide insight into the role of the response to DNA damage in radiation toxicity.