High-throughput laboratory evolution reveals global evolutionary constraints for antibiotic resistance - - GEO DataSets

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High-throughput laboratory evolution reveals global evolutionary constraints for antibiotic resistance

(Submitter supplied) Understanding constraints which shape antibiotic resistance is key for predicting and controlling drug resistance. Here, we performed high-throughput laboratory evolution of Escherichia coli. The transcriptome, resistance, and genomic profiles for the evolved strains in 48 environments were quantitatively analyzed. By analyzing the quantitative datasets through interpretable machine learning techniques, the emergence of low dimensional phenotypic states within the 192 strains was observed. more...

Organism:: Escherichia coli

Type:: Expression profiling by array

Platform:: GPL18948
196 Samples

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Accession:: GSE137348

ID:: 200137348

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