melan a vohipalensis - GEO DataSets

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Select item 2001696951.

DNA methylation analysis by DREAM of UV irradiated melanocytes

(Submitter supplied) Ultraviolet radiation (UVR) is the greatest risk factor for melanoma development. While the role of UVR in DNA mutagenesis is generally accepted, the role of UVR-induced mutations in melanomagenesis remains controversial. To understand better how UVR is contributing to melanoma development, we investigated the non-mutational effect of UVR on the epigenome, specifically DNA methylation. Aberrant DNA methylation changes are a hallmark in melanoma and there are few reports on the effects of UVR on DNA methylation. more...

Organism:: Homo sapiens; Mus musculus

Type:: Methylation profiling by high throughput sequencing

Platforms:: GPL16791 GPL17021
16 Samples

Download data: TXT

Series

Accession:: GSE169695

ID:: 200169695

SRA Run Selector

Select item 2002107932.

Tumor-specific cicrRNAs elicit anti-tumor immune response via encoding cryptic peptides

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing; Other

Platforms:: GPL24247 GPL24676
100 Samples

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Series

Accession:: GSE210793

ID:: 200210793

PubMed Similar studies

Select item 2002107913.

Tumor-specific circRNAs elicit anti-tumor immune response via encoding cryptic peptides [circRNA-seq of mouse]

(Submitter supplied) By using RNA-seq, we report circRNA profilings from B16F10 and melan-a, circRNA profilings from 4T1 and Eph4-ev.

Organism:: Mus musculus

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL24247
12 Samples

Download data: TXT

Series

Accession:: GSE210791

ID:: 200210791

PubMed Similar studies

Select item 2002122784.

Cancer-specific alternative polyadenylation shapes tumor phenotypes in vivo

(Submitter supplied) Alternative polyadenylation (APA) is strikingly dysregulated in many cancers. Although APA dysregulation is frequently associated with poor prognosis, the biological importance of most APA events remains unclear simply because few have been functionally studied. Here, we performed a CRISPR/Cas9-based screen to assess individual APA events’ contributions to tumor growth in vivo. Forcing use of specific polyadenylation sites altered mRNA and protein levels to modify mouse melanoma growth in an immunocompetent host. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL16417
12 Samples

Download data: CSV, TXT

Series

Accession:: GSE212278

ID:: 200212278

PubMed Full text in PMC Similar studies

Select item 2001287575.

Melan-a cells expressing reduced level of Dicer and control Melan-a cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; synthetic construct

Type:: Expression profiling by array; Non-coding RNA profiling by array

Platforms:: GPL21572 GPL20258
24 Samples

Download data: CEL

Series

Accession:: GSE128757

ID:: 200128757

Analyze with GEO2R

Select item 2001287566.

Gene expression data from Melan-a cells expressing reduced level of Dicer and control Melan-a cells [48 hours]

(Submitter supplied) To investigate the molecular mechanism of the hypopigmentation observed in Dicer KO mice, Dicer knockdown was realised in vitro in normal C57BL/6 mouse melanocyte Melan-a cells. Transient transfection of Melan-a cells with siRNA directed against Dicer reduced Dicer protein levels to approximately 40% of that of siScr Melan-a cells 48 hours after transfection. We analyzed the transcriptome of Melan-a cells 48 hours after transfection with siDicer or siScr to understand the molecular mechanisms involved in Dicer-dependent melanocyte migration.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL20258
6 Samples

Download data: CEL

Series

Accession:: GSE128756

ID:: 200128756

Analyze with GEO2R

Select item 2001287557.

Gene expression data from Melan-a cells expressing reduced level of Dicer and control Melan-a cells [24 hours]

(Submitter supplied) To investigate the molecular mechanism of the hypopigmentation observed in Dicer KO mice, Dicer knockdown was realised in vitro in normal C57BL/6 mouse melanocyte Melan-a cells. Transient transfection of Melan-a cells with siRNA directed against Dicer reduced Dicer protein levels to approximately 40% of that of siScr Melan-a cells 24 hours after transfection. We analyzed the transcriptome of Melan-a cells 24 hours after transfection with siDicer or siScr to understand the molecular mechanisms involved in Dicer-dependent melanocyte migration.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL20258
6 Samples

Download data: CEL

Series

Accession:: GSE128755

ID:: 200128755

Analyze with GEO2R

Select item 2001287548.

microRNA levels data from Melan-a cells expressing reduced level of Dicer and control Melan-a cells

(Submitter supplied) To investigate the molecular mechanism of the hypopigmentation observed in Dicer KO mice, Dicer knockdown was realised in vitro in normal C57BL/6 mouse melanocyte Melan-a cells. Transient transfection of Melan-a cells with siRNA directed against Dicer reduced Dicer protein levels to approximately 40% of that of siScr Melan-a cells 24 hours after transfection. We analyzed the miRnome of Melan-a cells 24 and 48 hours after transfection with siDicer or siScr to understand the molecular mechanisms involved in Dicer-dependent melanocyte migration.

Organism:: Mus musculus; synthetic construct

Type:: Non-coding RNA profiling by array

Platform:: GPL21572
12 Samples

Download data: CEL

Series

Accession:: GSE128754

ID:: 200128754

Analyze with GEO2R

Select item 2001601129.

Combined Inhibition of Gaq and MEK Enhances Therapeutic Efficacy in Uveal Melanoma

(Submitter supplied) We developed an isogenic melanocytic cellular system and systematically examined the hotspot mutations in GNAQ (e.g., G48V, R183Q, Q209L) and CYSLTR2 (e.g. L129Q) in human uveal melanoma. Biochemical and cell viability assays validated YM-254890 as a potent inhibitor of cell signaling and growth. Human uveal melanoma cells and mouse models recapitulated this finding, indicating that YM is also effective in vivo. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
6 Samples

Download data: CSV

Series

Accession:: GSE160112

ID:: 200160112

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20015270510.

Combined Inhibition of Gaq and MEK Enhances Therapeutic Efficacy in Uveal Melanoma.

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL13112 GPL11154
28 Samples

Download data: CSV

Series

Accession:: GSE152705

ID:: 200152705

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20016309611.

Expression data from mouse melanocytes and melanoma

(Submitter supplied) Melan-a cells were transduced with control vector and c-kit(K641E) to generate mVec and mKitK641E(PT) cell lines. mKitK641E(T) cells were generated by extracting cells from in vivo tumor growth of mKitK641E(PT) cells. We used microarrays to detail the global programme of gene expression of mVec, mKitK641E(PT) and mKitK641E(T) cell lines.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL23038
6 Samples

Download data: CEL

Series

Accession:: GSE163096

ID:: 200163096

Analyze with GEO2R

Select item 20014988412.

The transcriptome of a murine model of melanoma initiation and progression unravels molecular signatures of phenotype switch and novel independent prognostic factors for melanoma patients

(Submitter supplied) Despite advances in therapeutics, the progression of melanoma to metastasis still confers a poor outcome to patients. Nevertheless, there is a lack of biological models to understand cellular and molecular changes taking place along disease progression. Here, we analyzed the transcriptome of a multi-stage murine model of melanoma progression comprising a non-tumorigenic melanocyte lineage (melan-a), pre-malignant melanocytes (4C), non-metastatic (4C11-) and metastasis-prone (4C11+) melanoma cells. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18480
11 Samples

Download data: TXT

Series

Accession:: GSE149884

ID:: 200149884

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20011834913.

Acute activation of ER-RAC1 P29S in melanocytes

(Submitter supplied) We studied the effects of acute activation of the melanoma oncogene RAC1 P29S using a tamoxifen-inducible ER-fusion protein system in mouse melanocytes

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
18 Samples

Download data: TXT

Series

Accession:: GSE118349

ID:: 200118349

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20011834314.

Endogenous RAC1 P29S in mouse melanocytes

(Submitter supplied) We studied the effects of long-term endogenous expression of the melanoma oncogene RAC1 P29S using melanocyte cultures isolated from transgenic mice

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
6 Samples

Download data: TXT

Series

Accession:: GSE118343

ID:: 200118343

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20009389515.

Keap1 knockdown in melanocytes induces cell proliferation and survival via HO-1-associated β-catenin signaling

(Submitter supplied) Nrf2-Keap1 signaling pathway protects cells against photo-oxidative stress. Yet in recent works, its role in melanogenesis together with cell protection functions against oxidative stress has been gaining interest. However, its effect on melanogenesis still has contradictory results from different studies. The aims of our study were to investigate the effect of Keap1 silencing in melanocyte on melanogenesis and its associated mechanism. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
2 Samples

Download data: WIG

Series

Accession:: GSE93895

ID:: 200093895

Analyze with GEO2R SRA Run Selector

Select item 20007161016.

Expression data from parental B16F0 cells and B16F0 exosomes [MoEx]

(Submitter supplied) As a type of secreted membrane vesicle, exosomes are emerging as an important mode of cell-to-cell communication. The objective of this study was to compare the abundance of transcripts present in the parental B16F0 cell to transcripts present in exosomes isolated from B16F0 conditioned media. Identifying local mechanisms of immunosuppression is a key barrier for expanding the clinical benefit of cancer immunotherapy. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6096
8 Samples

Download data: CEL

Series

Accession:: GSE71610

ID:: 200071610

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20008655517.

Identification of hypoxia-induced HIF1A targets in melanocytes reveals a molecular profile associated with poor prognosis for melanoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL16570 GPL17021
18 Samples

Download data: CEL, TXT, WIG

Series

Accession:: GSE86555

ID:: 200086555

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20008655318.

Identification of hypoxia-induced HIF1A targets in melanocytes reveals a molecular profile associated with poor prognosis for melanoma [gene expression]

(Submitter supplied) These datasets describe a melanocyte specific, HIF1A-Dependent / Hypoxia-Responsive gene expression signature defined by the regulation of genes critical to metabolism, chromatin and transcriptional regulation, vascularization and cellular invasivness. These genes provide lineage specific targets for refinement of diagnostic markers associated with primary melanoma tumor metastatic potential, and also provides novel molecular targets for therapeutic strategies targeting metastatic disease progression.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
15 Samples

Download data: CEL

Series

Accession:: GSE86553

ID:: 200086553

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007295319.

TFAP2A ChIP-seq in mouse immortalized melanocytes

(Submitter supplied) Damage to the gene regulatory network governing terminal differentiation of melanocytes leads to pigmentation phenotypes and increases the risk for melanoma. Microphthalmia-associated transcription factor (MITF) directly activates expression of melanocyte differentiation effectors, and levels of MITF have been proposed to govern the melanoma phenotype. Mutations in the gene encoding Transcription Factor Activator Protein 2 alpha (TFAP2A) cause reduced pigmentation in model organisms and premature hair graying in humans, and TFAP2A expression tends to be lower in advanced melanoma tumors than in benign nevi. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11002
3 Samples

Download data: BIGWIG, NARROWPEAK

Series

Accession:: GSE72953

ID:: 200072953

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20008705120.

Transcriptome and gene/transcript expression profiling in melan-a cells

(Submitter supplied) The melan-a cell line is derived from immortalized mouse melanocytes obtained from Ink4a-ARF-/- mice. RNA-seq was performed to assess the global nature of transcript and gene expression profiles in melan-a cells. These RNA-seq data, along with separate ChIP-seq performed in melan-a cells (GSE38498), were used to correlate gene expression patterns with the presence or absence of transcription factors of interest.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
3 Samples

Download data: TXT

Series

Accession:: GSE87051

ID:: 200087051

PubMed Full text in PMC Similar studies SRA Run Selector

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