G9a histone methyltransferase maintains genomic imprinting in the mouse placenta. - - GEO DataSets

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G9a histone methyltransferase maintains genomic imprinting in the mouse placenta.

(Submitter supplied) Whereas DNA methylation is essential for genomic imprinting, the importance of histone methylation in the allelic repression of imprinted genes is unclear. ‘Imprinting control regions’ (ICRs), however, are consistently marked by histone H3 K9 methylation on their DNA-methylated allele. In the placenta, the paternal silencing along the Kcnq1 domain on distal chromosome 7 also correlates with the presence of H3-K9 methylation, but imprinted repression at these genes is maintained independently of DNA methylation. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL339 GPL1261 GPL340
6 Samples

Download data: CEL, CHP

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Accession:: GSE7674

ID:: 200007674

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