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Items: 4

1.

Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells

(Submitter supplied) In the course of primary infection with herpes simplex virus 1 (HSV-1), children with inborn errors of the TLR3- and UNC-93B-dependent induction of IFN-α/β and/or IFN-λ immunity are prone to HSV-1 encephalitis (HSE) 1-3. The cells responsible for HSE in these children have yet to be identified. We tested the hypothesis that the pathogenesis of HSE involves non hematopoietic central nervous system (CNS)-resident cells. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS4538 GDS4669
Platform:
GPL6884
18 Samples
Download data: TXT
Series
Accession:
GSE40593
ID:
200040593
2.
Full record GDS4669

Central nervous system cell types derived from UNC-93B-deficient induced pluripotent stem cells

Analysis of neurons and astrocytes derived from UNC-93B-deficient induced pluripotent stem cells (UNC93B-/- iPS) and from hESCs (H9). UNC-93B-/- neurons are highly susceptible to herpes simplex virus 1 (HSV-1) infection. Results provide insight into role of neurons in anti-HSV-1 immunity in the CNS.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 cell line, 3 cell type sets
Platform:
GPL6884
Series:
GSE40593
13 Samples
Download data
3.

Illumina HumanWG-6 v3.0 expression beadchip

(Submitter supplied) The HumanWG-6 v3.0 Expression BeadChip features up-to-date content derived from the National Center for Biotechnology Information Reference Sequence (NCBI RefSeq) database (Build 36.2, Release 22). Please use the GEO Data Submission Report Plug-in v1.0 for Gene Expression which may be downloaded from https://icom.illumina.com/icom/software.ilmn?id=234 to format the normalized and raw data. These should be submitted as part of a GEOarchive. more...
Organism:
Homo sapiens
9 DataSets
324 Series
9525 Samples
Download data: BGX
Platform
Accession:
GPL6884
ID:
100006884
4.

UNC93b-/- iPS-derived neurons CD44- EGFR- biological rep 1-2

Organism:
Homo sapiens
Source name:
Neurons CD44- EGFR- from UNC93B-/-
Platform:
GPL6884
Series:
GSE40593
Dataset:
GDS4669
Download data
Sample
Accession:
GSM997570
ID:
300997570
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