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Items: 4

1.

The gamma secretase inhibitor MRK-003 attenuates pancreatic cancer growth in preclinical models

(Submitter supplied) Pancreatic ductal adenocarcinoma (PDAC) is a nearly uniformly lethal malignancy, with most patients facing an adverse clinical outcome. Given the pivotal role of aberrant Notch signaling in the initiation and progression of PDAC, we investigated the effect of MRK-003, a potent and selective γ-secretase inhibitor, in preclinical PDAC models. We used a panel of human PDAC cell lines, as well as patient-derived PDAC xenografts, to determine whether pharmacological targeting of the Notch pathway could inhibit pancreatic tumor growth and potentiate gemcitabine sensitivity. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4342
Platform:
GPL570
18 Samples
Download data: CEL
Series
Accession:
GSE37645
ID:
200037645

PubMed Full text in PMC Similar studies Analyze with GEO2R

2.
Full record GDS4342

Gamma secretase inhibitor MRK-003 effect on pancreatic ductal adenocarcinoma tumor xenografts

Analysis of 9 individual patient-derived, pancreatic ductal adenocarcinoma (PDAC) xenografts treated with GSI MRK-003. MRK-003 monotherapy significantly reduced tumor volume in 5 of 9 xenografts. Results provide insight into the molecular basis of MRK-003-mediated attenuation of PDAC.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 9 cell line, 2 other sets
Platform:
GPL570
Series:
GSE37645
18 Samples
Download data: CEL
DataSet
Accession:
GDS4342
ID:
4342

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

3.

[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...
Organism:
Homo sapiens
602 DataSets
5669 Series
61 Related Platforms
174579 Samples
Download data
Platform
Accession:
GPL570
ID:
100000570

4.

Panc265 xenograft GSI_265A Sensitive to MRK-003

Organism:
Homo sapiens
Source name:
pancreatic ductal adenocarcinoma cell lines
Platform:
GPL570
Series:
GSE37645
Dataset:
GDS4342
Download data: CEL
Sample
Accession:
GSM924994
ID:
300924994

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