GSM924981[Accession] - GEO DataSets

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Items: 4

Select item 2000376451.

The gamma secretase inhibitor MRK-003 attenuates pancreatic cancer growth in preclinical models

(Submitter supplied) Pancreatic ductal adenocarcinoma (PDAC) is a nearly uniformly lethal malignancy, with most patients facing an adverse clinical outcome. Given the pivotal role of aberrant Notch signaling in the initiation and progression of PDAC, we investigated the effect of MRK-003, a potent and selective γ-secretase inhibitor, in preclinical PDAC models. We used a panel of human PDAC cell lines, as well as patient-derived PDAC xenografts, to determine whether pharmacological targeting of the Notch pathway could inhibit pancreatic tumor growth and potentiate gemcitabine sensitivity. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4342
Platform:: GPL570
18 Samples

Download data: CEL

Series

Accession:: GSE37645

ID:: 200037645

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 43422.

Gamma secretase inhibitor MRK-003 effect on pancreatic ductal adenocarcinoma tumor xenografts

Analysis of 9 individual patient-derived, pancreatic ductal adenocarcinoma (PDAC) xenografts treated with GSI MRK-003. MRK-003 monotherapy significantly reduced tumor volume in 5 of 9 xenografts. Results provide insight into the molecular basis of MRK-003-mediated attenuation of PDAC.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 9 cell line, 2 other sets

Platform:: GPL570
Series:: GSE37645
18 Samples

Download data: CEL

DataSet

Accession:: GDS4342

ID:: 4342

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 1000005703.

[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...