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Items: 3

1.

Heritable human Polycomb silencing is locus-dependent and requires H2AK119ub1 self-propagation

(Submitter supplied) Heritable gene silencing is essential for the development of multicellular organisms. Polycomb repressive complexes 1 and 2 (PRC1 and 2) catalyze and recognize histone H2A lysine 119 mono-ubiquitination (H2AK119ub1) and histone H3 lysine 27 trimethylation (H3K27me3), respectively, to mediate heritable gene silencing, but the mechanism of inheritance is not fully understood. Using an inducible gene silencing strategy, we show that the epigenetic inheritance of Polycomb silencing in human cells is strongly dependent on local DNA sequences and chromatin environment. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL18573
48 Samples
Download data: BW, FASTA
Series
Accession:
GSE209986
ID:
200209986

PubMed Full text in PMC Similar studies

2.

Illumina NextSeq 500 (Homo sapiens)

Organism:
Homo sapiens
12534 Series
342121 Samples
Download data
Platform
Accession:
GPL18573
ID:
100018573

3.

WT1,EEDKO,DoxycyclineRemoval, H3K27me3, Rep1

Organism:
Homo sapiens
Source name:
HEK293FT
Platform:
GPL18573
Series:
GSE209986
Download data: BW
Sample
Accession:
GSM6412284
ID:
306412284

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db=gds|term=GSM6412284[Accession]|query=2|qty=2|blobid=MCID_672b6d62b70df60c4d3f7b86|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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