GSM565186[Accession] - GEO DataSets

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Items: 4

Select item 2000228751.

OTX2 drives medulloblastoma proliferation via direct regulation of cell cycle genes and inhibits differentiation

(Submitter supplied) The transcription factor OTX2 has been implicated as an oncogene in medulloblastoma, which is the most common malignant brain tumor in children. It is highly expressed in most medulloblastomas and amplified in a subset of them. The role of OTX2 in medulloblastoma and its downstream targets are unclear. Therefore, we generated D425 medulloblastoma cells in which we can silence endogenous OTX2 by inducible shRNA. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4472
Platform:: GPL570
24 Samples

Download data: CEL

Series

Accession:: GSE22875

ID:: 200022875

Select item 44722.

Transcription factor OTX2 oncogene silencing effect on D425 medulloblastoma cell line: time course

Analysis of D425 medulloblastoma (MB) cells with doxycyline inducible shRNA against OTX2, sampled 0 to 96 hrs after induction in 3 independent time courses (TC). OTX2 is implicated as an oncogene in childhood MB. Results provide insight into role of OTX2 in medulloblastoma.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 4 other, 2 protocol, 6 time sets

Platform:: GPL570
Series:: GSE22875
24 Samples

Download data: CEL

DataSet

Accession:: GDS4472

ID:: 4472

Select item 1000005703.

[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...