GSM549888[Accession] - GEO DataSets

Select item 2000448651.

Vitamin-D Responsive SGPP2 Variants Associated with Lung Cell Expression and Lung Function

(Submitter supplied) Background: Vitamin D is associated with lung health in epidemiologi studies, but mechanisms mediating observed associations are poorly understood. This study explores mechanisms for an effect of vitamin D in lung through an in vivo gene expression study, an expression quantitative trait loci (eQTL) analysis in lung tissue, and a population-based cohort study of sequence variants. Methods: Microarray analysis investigated the association of gene expression in small airway epithelial cell with serum 25[OH]D in adult nonsmokers. more...

Organism:: Homo sapiens

Type:: Expression profiling by array; SNP genotyping by SNP array; Genome variation profiling by SNP array

Platforms:: GPL6804 GPL570
142 Samples

Download data: CEL, CHP

Series

Accession:: GSE44865

ID:: 200044865

Analyze with GEO2R

Select item 2000230872.

Genotype-Smoking Environment Interactions affecting eQTL in the Human Lung

(Submitter supplied) Background: Cases where genotype-phenotype relationships depend on environmental factors have been quantified for many complex diseases. Such genotype-environment interactions (GEI or GxE) may also affect expression Quantitative Trait Loci (eQTL) present in tissues critical for the manifestation of disease. To assess this hypothesis, we performed an analysis of eQTL-GEI resulting from an individual's smoking environment in the lung small airway epithelium (SAE). more...

Organism:: Homo sapiens

Type:: Expression profiling by array; SNP genotyping by SNP array

Platforms:: GPL570 GPL6804
180 Samples

Download data: CEL, CHP

Series

Accession:: GSE23087

ID:: 200023087

Analyze with GEO2R

Select item 2000403643.

eQTL analysis of many thousands of expressed genes while simultaneously controlling for hidden factors

(Submitter supplied) Motivation: Identification of eQTL, the genetic loci that contribute to heritable variation in gene expression, can be obstructed by factors that produce variation in expression profiles if these factors are unmeasured or hidden from direct analysis. Methods: We have developed a method for Hidden Expression Factor analysis (HEFT) that identifies individual and pleiotropic effects of eQTL in the presence of hidden factors. more...

Organism:: Homo sapiens

Type:: Expression profiling by array; SNP genotyping by SNP array

Platforms:: GPL6804 GPL570
232 Samples

Download data: CEL, CHP, TXT

Series

Accession:: GSE40364

ID:: 200040364

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000220474.

Modulation of Cystatin A Expression in Human Airway Epithelium Related to Genotype, Smoking COPD and Lung Cancer

(Submitter supplied) Cystatin A (gene: CSTA), is up-regulated in non-small-cell lung cancer (NSCLC) and dysplastic vs normal human bronchial epithelium. In the context that chronic obstructive pulmonary disease (COPD), a small airway epithelium (SAE) disorder, is independently associated with NSCLC (especially squamous cell carcinoma, SCC), but only occurs in a subset of smokers, we hypothesized that genetic variation, smoking and COPD modulate CSTA gene expression levels in SAE, with further up-regulation in SCC. more...

Organism:: Homo sapiens

Type:: Expression profiling by array; SNP genotyping by SNP array

Platforms:: GPL570 GPL6804
342 Samples

Download data: CEL, CHP, TXT

Series

Accession:: GSE22047

ID:: 200022047

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000068045.

[GenomeWideSNP_5] Affymetrix Genome-Wide Human SNP 5.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html The SNP Array 5.0 is a single microarray featuring all single nucleotide polymorphisms (SNPs) from the original two-chip Mapping 500K Array Set, as well as 420,000 additional non-polymorphic probes that can measure other genetic differences, such as copy number variation. more...

Organism:: Homo sapiens

14 Series
1 Related Platform
751 Samples

Download data

Platform

Accession:: GPL6804

ID:: 100006804

Select item 3005498886.

DGM-00013_gt

Organism:: Homo sapiens

Source name:: Blood from healthy nonsmokers or healthy smokers

Platform:: GPL6804
Series:: GSE22047 GSE23087 GSE40364 GSE44865

Download data: CEL, CHP

Sample

Accession:: GSM549888

ID:: 300549888

GEO DataSets

Functional Genomics Studies

Result Filters

Entry type

Organism

Study type

Author

Attribute name

Publication dates

Custom date range

Additional filters

Send to:

Search results

Items: 6

Send to:

Supplemental Content

Find related data

Search details

Important Links

Recent activity