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Items: 4

1.

STAR RNA-binding protein, Quaking, suppresses cancer via regulation of microRNA

(Submitter supplied) MicroRNAs have emerged as major genetic elements in the genesis and suppression of cancer. Here, multi-dimensional cancer genome analysis and validation has defined a novel Glioblastoma Multiforme (GBM) tumor suppressor pathway and mechanism of action centered on Quaking (QK), a member of the STAR family of RNA-binding proteins. Combined functional, biochemical and computational studies establish that p53 directly regulates QK gene expression, QK protein binds and stabilizes miR-20a of the cancer-relevant miR-17-92 cluster, and miR-20a in turn functions to regulate TGFβR2 and the TGFβ signaling network. more...
Organism:
Homo sapiens; Human alphaherpesvirus 1; Human betaherpesvirus 5; Betapolyomavirus hominis; Mus musculus; Rattus norvegicus; Murid betaherpesvirus 1; JC polyomavirus; Human immunodeficiency virus 1; Human gammaherpesvirus 8; Murid gammaherpesvirus 4; human gammaherpesvirus 4; Betapolyomavirus macacae
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platforms:
GPL1261 GPL7723 GPL570
48 Samples
Download data: CEL, TXT
Series
Accession:
GSE19693
ID:
200019693

PubMed Full text in PMC Similar studies Analyze with GEO2R

2.

microRNA expression of Hs683 and U87

(Submitter supplied) To identify QK-modulated microRNAs exhibiting a >1.5-fold change across all three cell model systems: human GBM cell lines, U87 and Hs683, and Ink4a/Arf-/- Pten-/- mouse astrocytes
Organism:
Homo sapiens; Murid gammaherpesvirus 4; Betapolyomavirus hominis; Rattus norvegicus; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; human gammaherpesvirus 4; JC polyomavirus; Human gammaherpesvirus 8; Betapolyomavirus macacae
Type:
Non-coding RNA profiling by array
Platform:
GPL7723
12 Samples
Download data: TXT
Series
Accession:
GSE19691
ID:
200019691

PubMed Full text in PMC Similar studies Analyze with GEO2R

3.

miRCURY LNA microRNA Array, v.11.0 - hsa, mmu & rno

(Submitter supplied) Array covering Sanger miRBase 12.0 and Exiqon miRPlus mature miRNAs. The platform information provided is from the time of the design. Names, accession numbers and sequences are listed for mature miRNAs in miRBase 12.0. Some probes may target multiple miRNAs, in which case multiple miRNA names, accession numbers and sequences are listed separated by '/' Protocol: See manufacturers website
Organism:
Homo sapiens; Mus musculus; Rattus norvegicus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; human gammaherpesvirus 4; JC polyomavirus; Human immunodeficiency virus 1; Murid gammaherpesvirus 4; Human gammaherpesvirus 8; Betapolyomavirus hominis; Betapolyomavirus macacae
58 Series
575 Samples
Download data
Platform
Accession:
GPL7723
ID:
100007723

4.

U-1.2

Organism:
Homo sapiens
Source name:
U87 (channel 1) Common reference Pool (channel 2)
Platform:
GPL7723
Series:
GSE19691 GSE19693
Download data: TXT
Sample
Accession:
GSM491556
ID:
300491556

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db=gds|term=GSM491556[Accession]|query=4|qty=14|blobid=MCID_67342851951b4d01ee1a9baf|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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