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GEO DataSets

Functional Genomics Studies

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Items: 4

Select item 2001465441.

Acute myeloid leukemia cells resist chemotherapy through a transient senescence-like state

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Expression profiling by array

Platforms:: GPL28228 GPL16791 GPL20301
36 Samples

Download data: CEL, MTX, TSV, TXT

Series

Accession:: GSE146544

ID:: 200146544

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001450612.

Acute myeloid leukemia cells resist chemotherapy through a transient senescence-like state [RNA-seq]

(Submitter supplied) In acute myeloid leukemias (AML), chemotherapy is frequently followed by disease relapse, yet the mechanism by which AML reemerges is not fully understood. We hypothesized that chemotherapy induces senescence-like dormancy that facilitates survival to genotoxic exposure, allowing AML cells to endure treatment in a transiently dormant state while retaining potential for leukemic repopulation. Here, we show that primary AML cells exhibit hallmark senescence features following treatment with cytarabine (AraC), including growth arrest, increased cellular granularity, senescence-associated-β-galactosidase (SA-β-gal) activity, and senescence-associated transcriptomic alterations. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
10 Samples

Download data: TXT

Series

Accession:: GSE145061

ID:: 200145061

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 1000167913.

Illumina HiSeq 2500 (Homo sapiens)

Organism:: Homo sapiens

12172 Series
349192 Samples

Platform

Accession:: GPL16791

ID:: 100016791

Select item 3043055574.

Sample_3_AML1566_Vehicle_repl3_RNAseq

Organism:: Homo sapiens

Source name:: AML ex vivo

Platform:: GPL16791
Series:: GSE145061 GSE146544

Download data: TXT

Sample

Accession:: GSM4305557

ID:: 304305557

SRA Run Selector

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GSM4305557[Accession] (4)
GEO DataSets
cytochrome oxidase subunit 1, partial (mitochondrion) [Agrionoptera insignis]
cytochrome oxidase subunit 1, partial (mitochondrion) [Agrionoptera insignis]
gi|1770602068|gb|QFU29408.1|

Protein
Xenopus laevis mitochondrial ribosomal protein L15, mRNA (cDNA clone MGC:83331 I...
Xenopus laevis mitochondrial ribosomal protein L15, mRNA (cDNA clone MGC:83331 IMAGE:6864535), complete cds
gi|50603721|gb|BC077536.1|

Nucleotide
Malaria Today - Saving Lives, Buying Time
Malaria Today - Saving Lives, Buying Time
Xenopus laevis MGC82059 protein, mRNA (cDNA clone MGC:82059 IMAGE:7011354), comp...
Xenopus laevis MGC82059 protein, mRNA (cDNA clone MGC:82059 IMAGE:7011354), complete cds
gi|49522917|gb|BC075162.1|

Nucleotide

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