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Items: 3

1.

Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer

(Submitter supplied) We found in this study through targeted CRISPR-Cas9 screening of RBPs that disrupting YTHDF2-dependent degradation of its target transcripts triggers apoptosis of MYC-dependent cancer cells and tumors. Enhanced CLIP (eCLIP), m6A-sequencing (m6A-seq) and YTHDF2 knockdown followed by RNA-seq analysis of YTHDF2-m6A-mRNA interactions revealed extensive associations with mRNAs encoding MAPK pathway genes that when stabilized, induce epithelial-to-mesenchymal transition and stress-induced apoptosis. more...
Organism:
Homo sapiens; synthetic construct
Type:
Expression profiling by high throughput sequencing; Other
Platforms:
GPL24676 GPL20301 GPL21616
74 Samples
Download data: BED, BED12, BW, TXT
Series
Accession:
GSE137258
ID:
200137258
2.

Illumina HiSeq 4000 (Homo sapiens)

Platform
Accession:
GPL20301
ID:
100020301
3.

MYC_HMEC_SMINPUT_rep2 [eCLIP-seq]

Organism:
Homo sapiens
Source name:
MYC-ER HMEC
Platform:
GPL20301
Series:
GSE137258
Download data: BW
Sample
Accession:
GSM4073989
ID:
304073989
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db=gds|term=GSM4073989[Accession]|query=1|qty=3|blobid=MCID_6624b3864c13c13a065ec5dd|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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