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Items: 3

1.

iRhom2 Promotes Lupus Nephritis through ADAM17-Dependent TNF-α and EGFR Signaling

(Submitter supplied) Lupus nephritis (LN) often results in progressive renal dysfunction. The inactive Rhomboid 2 (iRhom2) is a newly identified key regulator of A disintegrin and metalloprotease 17 (ADAM17), whose substrates, such as TNF-α and heparin-binding EGF (HB-EGF), have been implicated in the pathogenesis of chronic kidney disease. Here we demonstrate that deficiency of iRhom2 protects the lupus-prone Fcgr2b-/- mice from developing severe kidney damage without altering anti-double stranded (ds) DNA Ab production, by simultaneously blocking the HB-EGF/EGFR and the TNF-α signaling in the kidney tissues. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
28 Samples
Download data: CSV
Series
Accession:
GSE107705
ID:
200107705

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2.

Illumina HiSeq 2500 (Mus musculus)

Organism:
Mus musculus
11109 Series
299307 Samples
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Platform
Accession:
GPL17021
ID:
100017021

3.

iR2ko_355

Organism:
Mus musculus
Source name:
total kidney
Platform:
GPL17021
Series:
GSE107705
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Sample
Accession:
GSM2876265
ID:
302876265

SRA Run Selector

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db=gds|term=GSM2876265[Accession]|query=5|qty=2|blobid=MCID_6736ab1426808c4a205500fb|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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