(Submitter supplied) Targeting of general coactivators, such as BRD4, is an emerging strategy to interfere with oncogenic transcription factors (TFs) in cancer. However, coactivator perturbations have the potential to influence the function of numerous TFs, thereby resulting in biological pleiotropy. Here we identify TAF12, an 18 kilodalton subunit of TFIID/SAGA coactivator complexes, as a selective requirement for acute myeloid leukemia (AML) progression.
more...- Organism:
- Mus musculus; Homo sapiens
- Type:
- Expression profiling by high throughput sequencing
- Platforms:
- GPL13112 GPL11154
- 27 Samples
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