GSM2794817[Accession] - GEO DataSets

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Items: 4

Select item 2001043091.

A TFIID-SAGA perturbation that targets MYB and suppresses acute myeloid leukemia

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL13112 GPL11154
36 Samples

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Accession:: GSE104309

ID:: 200104309

PubMed Full text in PMC Similar studies

Select item 2001043082.

A TFIID-SAGA perturbation that targets MYB and suppresses acute myeloid leukemia (RNA-seq)

(Submitter supplied) Targeting of general coactivators, such as BRD4, is an emerging strategy to interfere with oncogenic transcription factors (TFs) in cancer. However, coactivator perturbations have the potential to influence the function of numerous TFs, thereby resulting in biological pleiotropy. Here we identify TAF12, an 18 kilodalton subunit of TFIID/SAGA coactivator complexes, as a selective requirement for acute myeloid leukemia (AML) progression. more...