(Submitter supplied) Endogenous retroviruses (ERVs), which make up 8% of the human genome, have been proposed to participate in the control of gene regulatory networks. In this study, we find a region- and developmental stage-specific expression pattern of ERVs in the developing human brain, which is linked to a transcriptional network based on ERVs. We demonstrate that almost ten thousand, primarily primate-specific ERVs, act as docking platforms for the epigenetic co-repressor protein TRIM28 in human neural progenitor cells, which results in the establishment of local heterochromatin.
more...- Organism:
- Homo sapiens
- Type:
- Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
- Platforms:
- GPL21290 GPL16791
- 34 Samples
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