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Items: 3

1.

Integrative genomics outlines a biphasic glucose response and a ChREBP-RORγ axis regulating proliferation in β-cells

(Submitter supplied) Glucose is an important regulator of pancreatic β-cell function. In addition to the acute stimulation of insulin secretion, glucose stimulates long-term adaptive changes in gene expression that can either promote or antagonize the proliferative potential and function of β-cells. The glucose-sensing transcription factor carbohydrate response element binding protein (ChREBP) has been shown to promote both β-cell proliferation and dysfunction; however, the molecular mechanisms underlying these pleiotropic effects of ChREBP and glucose are not well understood. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL18404
54 Samples
Download data: BEDGRAPH, TXT
Series
Accession:
GSE81628
ID:
200081628
2.

Illumina HiSeq 1500 (Rattus norvegicus)

Organism:
Rattus norvegicus
17 Series
268 Samples
Download data
Platform
Accession:
GPL18404
ID:
100018404
3.

DNase I 2h glucose

Organism:
Rattus norvegicus
Source name:
β-cell_DNase I 2h glucose
Platform:
GPL18404
Series:
GSE81628
Download data: BEDGRAPH
Sample
Accession:
GSM2159999
ID:
302159999
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db=gds|term=GSM2159999[Accession]|query=9|qty=2|blobid=MCID_6727317e9e21e62c156618d6|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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