GSM1904431[Accession] - GEO DataSets

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Items: 4

Select item 2000738471.

Functional characterization of RNA-binding protein IMP2 in primary Glioma cell lines

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing; Non-coding RNA profiling by array

4 related Platforms
31 Samples

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Series

Accession:: GSE73847

ID:: 200073847

Select item 2000738452.

Functional characterization of RNA-binding protein IMP2 in primary Glioma cell lines [HTS]

(Submitter supplied) Cancer stem cells (CSC) dictate tumor cell heterogeneity in diverse cancer types and arise, in part, from microRNA (miRNA)-dependent alteration of gene expression. The let-7 miRNA family induces differentiation by silencing genes that maintain stemness and is repressed by the RNA-binding proteins LIN28A/B, which preserve stemness in normal embryonic and malignant cells. Here, we observed that LIN28A/B is undetectable in glioma stem cells (GSC) whereas let-7 and, paradoxically, their target genes are highly expressed. more...