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Items: 3

1.

Drug specific epigenetic reprogramming leads to increased cellular invasion in ERα positive breast cancer via de novo cholesterol biosynthesis.

(Submitter supplied) Endocrine therapy resistance remains a critical problem in the treatment of estrogen receptor alpha (ERα) breast cancer. Endocrine therapies target ERα via different modes of action. Drug resistance involves drug specific remodeling of the transcriptional and regulatory landscape. Using epigenomics and transcriptomics, we demonstrate that resistance to aromatase inhibitors (AI) induces phenotypical changes through epigenetic activation of cholesterol biosynthesis (CB) and keratin 80. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL16791 GPL11154
10 Samples
Download data: BED, WIG
Series
Accession:
GSE60517
ID:
200060517
2.

Illumina HiSeq 2000 (Homo sapiens)

Platform
Accession:
GPL11154
ID:
100011154
3.

H3K27ac LTED

Organism:
Homo sapiens
Source name:
LTED
Platform:
GPL11154
Series:
GSE60517
Download data: WIG
Sample
Accession:
GSM1481573
ID:
301481573
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db=gds|term=GSM1481573[Accession]|query=1|qty=2|blobid=MCID_661f8803d4af9b208975a6aa|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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