GSM1481573[Accession] - GEO DataSets - NCBI

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Items: 3

Select item 2000605171.

Drug specific epigenetic reprogramming leads to increased cellular invasion in ERα positive breast cancer via de novo cholesterol biosynthesis.

(Submitter supplied) Endocrine therapy resistance remains a critical problem in the treatment of estrogen receptor alpha (ERα) breast cancer. Endocrine therapies target ERα via different modes of action. Drug resistance involves drug specific remodeling of the transcriptional and regulatory landscape. Using epigenomics and transcriptomics, we demonstrate that resistance to aromatase inhibitors (AI) induces phenotypical changes through epigenetic activation of cholesterol biosynthesis (CB) and keratin 80. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL16791 GPL11154
10 Samples

Download data: BED, WIG

Series

Accession:: GSE60517

ID:: 200060517

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 1000111542.

Illumina HiSeq 2000 (Homo sapiens)

Organism:: Homo sapiens

10550 Series
183623 Samples

Platform

Accession:: GPL11154

ID:: 100011154

Select item 3014815733.

Organism:: Homo sapiens

Source name:: LTED

Platform:: GPL11154
Series:: GSE60517

Download data: WIG

Sample

Accession:: GSM1481573

ID:: 301481573

SRA Run Selector

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