(Submitter supplied) We mapped long-range chromatin interactions in embryonic stem cells (ESCs), iPSCs, and fibroblasts, and uncovered an ESC-specific genome organization that is gradually re-established during reprogramming. Confirming previous results, we show that open, accessible and closed chromatin character is the primary determinant of long-range chromatin interaction preferences. Importantly, we find that in ESCs, genomic regions extensively occupied by the pluripotency factors Oct4, Sox2, and Nanog preferentially co-localize.
more...- Organism:
- Mus musculus
- Type:
- Other
- Platforms:
- GPL13112 GPL11002
- 201 Samples
Download data: BEDGRAPH, XLSX