GSM1187651[Accession] - GEO DataSets

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Items: 4

Select item 2000489631.

Targeting H3K4 methylation as a therapeutic strategy for Huntington's disease

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL11002 GPL13112
32 Samples

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Series

Accession:: GSE48963

ID:: 200048963

PubMed Full text in PMC Similar studies

Select item 2000489622.

Targeting H3K4 methylation as a therapeutic strategy for Huntington's disease (RNA-seq)

(Submitter supplied) Transcriptional dysregulation is an early feature of Huntington's disease (HD). We observed gene-specific changes in H3K4me3 at transcriptionally repressed promoters in R6/2 mouse and human HD brain. Genome-wide analysis showed a novel chromatin signature for this mark. Reducing the levels of the H3K4 demethylase SMCX/Jarid1c in primary neurons reversed down-regulation of key neuronal genes caused by mutant Huntingtin (Htt) expression. more...