GEO DataSets

(Submitter supplied) The “CTCF code” hypothesis posits that CTCF pleotropic functions are driven by recognition of diverse DNA sequences through combinatorial use of its 11 zinc fingers (ZFs). This model however is supported by in vitro binding studies of a limited number of sequences. To directly test CTCF multivalency in vivo we here define ZF binding requirements at ~50,000 genomic sites in primary lymphocytes. We find that CTCF reads sequence diversity through ZF clustering. more...

Organism:

Mus musculus; Mus spretus

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL17106 GPL9250 GPL13112

45 Samples

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