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Items: 3

1.

TRIM28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells

(Submitter supplied) TRIM28 (KAP1 - KRAB-associated protein 1) is critical for the silencing of endogenous retroviruses (ERVs) in embryonic stem (ES) cells. Here, we reveal that an essential impact of this process is the protection of cellular gene expression in early embryos from perturbation by cis-acting activators contained within these genetic invaders. In TRIM28-depleted ES cells, repressive chromatin marks at ERVs are replaced by histone modifications typical of active enhancers, stimulating transcription of nearby cellular genes, notably those harboring bivalent promoters. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL9250 GPL13112
18 Samples
Download data: BED, TXT, XLS
Series
Accession:
GSE41903
ID:
200041903

PubMed Full text in PMC Similar studies SRA Run Selector

2.

Illumina Genome Analyzer II (Mus musculus)

Organism:
Mus musculus
802 Series
5962 Samples
Download data
Platform
Accession:
GPL9250
ID:
100009250

3.

mRNA-seq: MEF KAP1 KO

Organism:
Mus musculus
Source name:
mRNA-seq: MEF KAP1 KO
Platform:
GPL9250
Series:
GSE41903
Download data
Sample
Accession:
GSM1032185
ID:
301032185

SRA Run Selector

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db=gds|term=GSM1032185[Accession]|query=7|qty=2|blobid=MCID_672eb1f24a68a644034b05da|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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