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Items: 1 to 20 of 24

1.

MLL-AF4 binds directly to a BCL-2 specific enhancer and impacts H3K27 acetylation

(Submitter supplied) Survival rates for children diagnosed with acute lymphoblastic leukemia (ALL) have drastically improved, but those carrying mutations in the Mixed Lineage Leukemia (MLL) gene continue to have a very poor prognosis. The most common MLL mutation in ALL is the t(4;11)(q21;q23) chromosome translocation that fuses MLL in frame with the AF4 gene producing MLL-AF4 and AF4-MLL fusion proteins. Previously, we showed that MLL-AF4 binds to the BCL-2 gene and directly activates it through DOT1L recruitment and increased H3K79me2/3 levels. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Other; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL18573 GPL16791
21 Samples
Download data: BW, TXT
Series
Accession:
GSE85988
ID:
200085988

PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector

2.

Illumina NextSeq 500 (Homo sapiens)

Organism:
Homo sapiens
12538 Series
342241 Samples
Download data
Platform
Accession:
GPL18573
ID:
100018573

3.

Illumina HiSeq 2500 (Homo sapiens)

Organism:
Homo sapiens
12192 Series
349329 Samples
Download data
Platform
Accession:
GPL16791
ID:
100016791

4.

RCH_input_all

Organism:
Homo sapiens
Source name:
Leukemia cell line (RCH-ACV)
Platform:
GPL16791
Series:
GSE85988
Download data: BW
Sample
Accession:
GSM2290174
ID:
302290174

5.

RCH_PBX_ChIPseq

Organism:
Homo sapiens
Source name:
Leukemia cell line (RCH-ACV)
Platform:
GPL16791
Series:
GSE85988
Download data: BW
Sample
Accession:
GSM2290173
ID:
302290173

6.

RCH_P300_ChIPseq

Organism:
Homo sapiens
Source name:
Leukemia cell line (RCH-ACV)
Platform:
GPL16791
Series:
GSE85988
Download data: BW
Sample
Accession:
GSM2290172
ID:
302290172

SRA Run Selector

7.

RCH_E2A_ChIPseq

Organism:
Homo sapiens
Source name:
Leukemia cell line (RCH-ACV)
Platform:
GPL16791
Series:
GSE85988
Download data: BW
Sample
Accession:
GSM2290171
ID:
302290171

8.

SEM_P300_input

Organism:
Homo sapiens
Source name:
Leukemia cell line (SEM)
Platform:
GPL16791
Series:
GSE85988
Download data: BW
Sample
Accession:
GSM2290170
ID:
302290170

9.

SEM_P300_ChIPseq

Organism:
Homo sapiens
Source name:
Leukemia cell line (SEM)
Platform:
GPL16791
Series:
GSE85988
Download data: BW
Sample
Accession:
GSM2290169
ID:
302290169

10.

SEM_E2A_input

Organism:
Homo sapiens
Source name:
Leukemia cell line (SEM)
Platform:
GPL16791
Series:
GSE85988
Download data: BW
Sample
Accession:
GSM2290168
ID:
302290168

11.

SEM_E2A_ChIPseq

Organism:
Homo sapiens
Source name:
Leukemia cell line (SEM)
Platform:
GPL16791
Series:
GSE85988
Download data: BW
Sample
Accession:
GSM2290167
ID:
302290167

12.

SEM_2umEPZ5676_Rep3

Organism:
Homo sapiens
Source name:
Leukemia cell line (SEM)
Platform:
GPL18573
Series:
GSE85988
Download data
Sample
Accession:
GSM2332451
ID:
302332451

SRA Run Selector

13.

SEM_2umEPZ5676_Rep2

Organism:
Homo sapiens
Source name:
Leukemia cell line (SEM)
Platform:
GPL18573
Series:
GSE85988
Download data
Sample
Accession:
GSM2332450
ID:
302332450

SRA Run Selector

14.

SEM_2umEPZ5676_Rep1

Organism:
Homo sapiens
Source name:
Leukemia cell line (SEM)
Platform:
GPL18573
Series:
GSE85988
Download data
Sample
Accession:
GSM2332449
ID:
302332449

SRA Run Selector

15.

SEM_0umEPZ5676_Rep3

Organism:
Homo sapiens
Source name:
Leukemia cell line (SEM)
Platform:
GPL18573
Series:
GSE85988
Download data
Sample
Accession:
GSM2332448
ID:
302332448

SRA Run Selector

16.

SEM_0umEPZ5676_Rep2

Organism:
Homo sapiens
Source name:
Leukemia cell line (SEM)
Platform:
GPL18573
Series:
GSE85988
Download data
Sample
Accession:
GSM2332447
ID:
302332447

SRA Run Selector

17.

SEM_0umEPZ5676_Rep1

Organism:
Homo sapiens
Source name:
Leukemia cell line (SEM)
Platform:
GPL18573
Series:
GSE85988
Download data
Sample
Accession:
GSM2332446
ID:
302332446

SRA Run Selector

18.

SEM_CaptureC

Organism:
Homo sapiens
Source name:
Leukemia cell line (SEM)
Platform:
GPL18573
Series:
GSE85988
Download data: TXT
Sample
Accession:
GSM2290166
ID:
302290166

19.

SEM_siMLLAF4_Rep3

Organism:
Homo sapiens
Source name:
Leukemia cell line (SEM)
Platform:
GPL18573
Series:
GSE85988
Download data
Sample
Accession:
GSM2290165
ID:
302290165

20.

SEM_siMLLAF4_Rep2

Organism:
Homo sapiens
Source name:
Leukemia cell line (SEM)
Platform:
GPL18573
Series:
GSE85988
Download data
Sample
Accession:
GSM2290164
ID:
302290164

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