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Items: 1 to 20 of 56

1.

Integrative genomics outlines a biphasic glucose response and a ChREBP-RORγ axis regulating proliferation in β-cells

(Submitter supplied) Glucose is an important regulator of pancreatic β-cell function. In addition to the acute stimulation of insulin secretion, glucose stimulates long-term adaptive changes in gene expression that can either promote or antagonize the proliferative potential and function of β-cells. The glucose-sensing transcription factor carbohydrate response element binding protein (ChREBP) has been shown to promote both β-cell proliferation and dysfunction; however, the molecular mechanisms underlying these pleiotropic effects of ChREBP and glucose are not well understood. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL18404
54 Samples
Download data: BEDGRAPH, TXT
Series
Accession:
GSE81628
ID:
200081628
2.

Illumina HiSeq 1500 (Rattus norvegicus)

Organism:
Rattus norvegicus
17 Series
268 Samples
Download data
Platform
Accession:
GPL18404
ID:
100018404
3.

DNase I 12h glucose

Organism:
Rattus norvegicus
Source name:
β-cell_DNase I 12h glucose
Platform:
GPL18404
Series:
GSE81628
Download data: BEDGRAPH
Sample
Accession:
GSM2160000
ID:
302160000
4.

DNase I 2h glucose

Organism:
Rattus norvegicus
Source name:
β-cell_DNase I 2h glucose
Platform:
GPL18404
Series:
GSE81628
Download data: BEDGRAPH
Sample
Accession:
GSM2159999
ID:
302159999
5.

DNase I 0h glucose

Organism:
Rattus norvegicus
Source name:
β-cell_DNase I 0h glucose
Platform:
GPL18404
Series:
GSE81628
Download data: BEDGRAPH
Sample
Accession:
GSM2159998
ID:
302159998
6.

Input 12h

Organism:
Rattus norvegicus
Source name:
β-cell_Input 12h
Platform:
GPL18404
Series:
GSE81628
Download data: BEDGRAPH
Sample
Accession:
GSM2159997
ID:
302159997
7.

Input 2h

Organism:
Rattus norvegicus
Source name:
β-cell_Input 2h
Platform:
GPL18404
Series:
GSE81628
Download data: BEDGRAPH
Sample
Accession:
GSM2159996
ID:
302159996
8.

Input 0h

Organism:
Rattus norvegicus
Source name:
β-cell_Input 0h
Platform:
GPL18404
Series:
GSE81628
Download data: BEDGRAPH
Sample
Accession:
GSM2159995
ID:
302159995
9.

ChREBP 12h glucose B

Organism:
Rattus norvegicus
Source name:
β-cell_ChREBP 12h glucose
Platform:
GPL18404
Series:
GSE81628
Download data: BEDGRAPH
Sample
Accession:
GSM2159994
ID:
302159994
10.

ChREBP 12h glucose A

Organism:
Rattus norvegicus
Source name:
β-cell_ChREBP 12h glucose
Platform:
GPL18404
Series:
GSE81628
Download data: BEDGRAPH
Sample
Accession:
GSM2159993
ID:
302159993
11.

ChREBP 2h glucose B

Organism:
Rattus norvegicus
Source name:
β-cell_ChREBP 2h glucose
Platform:
GPL18404
Series:
GSE81628
Download data: BEDGRAPH
Sample
Accession:
GSM2159992
ID:
302159992
12.

ChREBP 2h glucose A

Organism:
Rattus norvegicus
Source name:
β-cell_ChREBP 2h glucose
Platform:
GPL18404
Series:
GSE81628
Download data: BEDGRAPH
Sample
Accession:
GSM2159991
ID:
302159991
13.

ChREBP 0h glucose B

Organism:
Rattus norvegicus
Source name:
β-cell_ChREBP 0h glucose
Platform:
GPL18404
Series:
GSE81628
Download data: BEDGRAPH
Sample
Accession:
GSM2159990
ID:
302159990
14.

ChREBP 0h glucose A

Organism:
Rattus norvegicus
Source name:
β-cell_ChREBP 0h glucose
Platform:
GPL18404
Series:
GSE81628
Download data: BEDGRAPH
Sample
Accession:
GSM2159989
ID:
302159989
15.

MED1 12h glucose B

Organism:
Rattus norvegicus
Source name:
β-cell_MED1 12h glucose
Platform:
GPL18404
Series:
GSE81628
Download data: BEDGRAPH
Sample
Accession:
GSM2159988
ID:
302159988
16.

MED1 12h glucose A

Organism:
Rattus norvegicus
Source name:
β-cell_MED1 12h glucose
Platform:
GPL18404
Series:
GSE81628
Download data: BEDGRAPH
Sample
Accession:
GSM2159987
ID:
302159987
17.

MED1 2h glucose B

Organism:
Rattus norvegicus
Source name:
β-cell_MED1 2h glucose
Platform:
GPL18404
Series:
GSE81628
Download data: BEDGRAPH
Sample
Accession:
GSM2159986
ID:
302159986
18.

MED1 2h glucose A

Organism:
Rattus norvegicus
Source name:
β-cell_MED1 2h glucose
Platform:
GPL18404
Series:
GSE81628
Download data: BEDGRAPH
Sample
Accession:
GSM2159985
ID:
302159985
19.

MED1 0h glucose B

Organism:
Rattus norvegicus
Source name:
β-cell_MED1 0h glucose
Platform:
GPL18404
Series:
GSE81628
Download data: BEDGRAPH
Sample
Accession:
GSM2159984
ID:
302159984
20.

MED1 0h glucose A

Organism:
Rattus norvegicus
Source name:
β-cell_MED1 0h glucose
Platform:
GPL18404
Series:
GSE81628
Download data: BEDGRAPH
Sample
Accession:
GSM2159983
ID:
302159983
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Supplemental Content

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