GSE34475[Accession] - GEO DataSets - NCBI

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Items: 6

Select item 2000344751.

Degradation of cellular miR-27 by a novel, highly abundant viral transcript is important for efficient virus replication in vivo.

(Submitter supplied) Cytomegaloviruses express large amounts of viral miRNAs during lytic infection, yet, they only modestly alter the cellular miRNA profile. The most prominent alteration upon lytic murine cytomegalovirus (MCMV) infection is the rapid degradation of the cellular miR-27a and miR-27b. Here, we report that this regulation is mediated by the <1.7 kb spliced and highly abundant MCMV m169 transcript. Specificity to miR-27a/b is mediated by a single, apparently optimized, miRNA binding site located in its 3'-UTR. more...

Organism:: Mus musculus

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL11002
4 Samples

Series

Accession:: GSE34475

ID:: 200034475

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 1000110022.

Illumina Genome Analyzer IIx (Mus musculus)

Organism:: Mus musculus

896 Series
7716 Samples

Platform

Accession:: GPL11002

ID:: 100011002

Select item 3008498583.

Ago 2 immunoprecipitated RNA extracted from MCMV infected NIH-3T3 cells

Organism:: Mus musculus

Source name:: NIH-3T3_MCMV_Ago_IP

Platform:: GPL11002
Series:: GSE34475

Sample

Accession:: GSM849858

ID:: 300849858

SRA Run Selector

Select item 3008498574.

Ago 2 immunoprecipitated RNA extracted from mock infected NIH-3T3 cells

Organism:: Mus musculus

Source name:: NIH-3T3_mock_Ago2_IP

Platform:: GPL11002
Series:: GSE34475

Sample

Accession:: GSM849857

ID:: 300849857

SRA Run Selector

Select item 3008498565.

Total RNA extracted from MCMV infected NIH-3T3 cells

Organism:: Mus musculus

Source name:: NIH-3T3_MCMV

Platform:: GPL11002
Series:: GSE34475

Sample

Accession:: GSM849856

ID:: 300849856

SRA Run Selector

Select item 3008498556.

Total RNA extracted from mock infected NIH-3T3 cells

Organism:: Mus musculus

Source name:: NIH-3T3_mock

Platform:: GPL11002
Series:: GSE34475

Sample

Accession:: GSM849855

ID:: 300849855

SRA Run Selector

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