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Items: 6

1.

Degradation of cellular miR-27 by a novel, highly abundant viral transcript is important for efficient virus replication in vivo.

(Submitter supplied) Cytomegaloviruses express large amounts of viral miRNAs during lytic infection, yet, they only modestly alter the cellular miRNA profile. The most prominent alteration upon lytic murine cytomegalovirus (MCMV) infection is the rapid degradation of the cellular miR-27a and miR-27b. Here, we report that this regulation is mediated by the <1.7 kb spliced and highly abundant MCMV m169 transcript. Specificity to miR-27a/b is mediated by a single, apparently optimized, miRNA binding site located in its 3'-UTR. more...
Organism:
Mus musculus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL11002
4 Samples
Download data
Series
Accession:
GSE34475
ID:
200034475
2.

Illumina Genome Analyzer IIx (Mus musculus)

Platform
Accession:
GPL11002
ID:
100011002
3.

Ago 2 immunoprecipitated RNA extracted from MCMV infected NIH-3T3 cells

Organism:
Mus musculus
Source name:
NIH-3T3_MCMV_Ago_IP
Platform:
GPL11002
Series:
GSE34475
Download data
Sample
Accession:
GSM849858
ID:
300849858
4.

Ago 2 immunoprecipitated RNA extracted from mock infected NIH-3T3 cells

Organism:
Mus musculus
Source name:
NIH-3T3_mock_Ago2_IP
Platform:
GPL11002
Series:
GSE34475
Download data
Sample
Accession:
GSM849857
ID:
300849857
5.

Total RNA extracted from MCMV infected NIH-3T3 cells

Organism:
Mus musculus
Source name:
NIH-3T3_MCMV
Platform:
GPL11002
Series:
GSE34475
Download data
Sample
Accession:
GSM849856
ID:
300849856
6.

Total RNA extracted from mock infected NIH-3T3 cells

Organism:
Mus musculus
Source name:
NIH-3T3_mock
Platform:
GPL11002
Series:
GSE34475
Download data
Sample
Accession:
GSM849855
ID:
300849855
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Supplemental Content

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