GEO DataSets

(Submitter supplied) Comparison of mRNA expression showed widespread changes in the circulating CD8+ but not CD4+ T-cells from patients with severe asthma. No changes were observed in the CD4+ and CD8+ T-cells in non-severe asthmatics versus healthy controls. Bioinformatics analysis showed that the changes in CD8+ T-cell mRNA expression were associated with multiple pathways involved in T-cell activation. As with mRNAs, we also observed widespread changes in expression of non-coding RNA species including natural antisense, pseudogenes, intronic long ncRNAs and long intergenic long ncRNAs in CD8+ T-cells from severe asthmatics. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4425

Platform:

GPL570

40 Samples

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Analysis of circulating CD4+ and CD8+ T-cells from adult patients with severe or nonsevere asthma. CD4+ T cells contribute to the development and maintenance of an inflammatory response in asthmatic patients. Results provide insight into the role of CD8+ T cells in severe asthma.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 cell type, 3 disease state sets

Platform:

GPL570

Series:

GSE31773

40 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...

Organism:

Homo sapiens

602 DataSets

5669 Series

61 Related Platforms

174579 Samples

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