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Items: 8

1.

Specific silencing of pathogenic mRNA by a novel compact RNA-targeting tool TaqTth-hpRNA [RNA-seq]

(Submitter supplied) Pathogenic allele silencing is a promising treatment for genetic hereditary diseases. However, the concern about the specificity of present RNA-knockdown strategies has limited their in vivo applications. Here a TaqTth-hpRNA system consisting of a small, chimeric protein (TaqTth) and hairpin-RNA probe (hpRNA) is provided. The TaqTth-hpRNA showed a high-specific knockdown against targeted mRNA with minimal flanking sequence-motif requirement and less cell viability damage, then was applied to mutant APPswe mRNA silencing without altering the wild-type APP mRNA in Alzheimer’s disease. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
6 Samples
Download data: TXT
Series
Accession:
GSE269592
ID:
200269592

PubMed Full text in PMC Similar studies

2.

Illumina HiSeq 4000 (Homo sapiens)

Organism:
Homo sapiens
8493 Series
195028 Samples
Download data
Platform
Accession:
GPL20301
ID:
100020301

3.

RNA-Seq of HEK293T:D1_Cas13_T

Organism:
Homo sapiens
Source name:
cell line
Platform:
GPL20301
Series:
GSE269592
Download data: TXT
Sample
Accession:
GSM8322620
ID:
308322620

SRA Run Selector

4.

RNA-Seq of HEK293T:C2_Cas13_NT

Organism:
Homo sapiens
Source name:
cell line
Platform:
GPL20301
Series:
GSE269592
Download data: TXT
Sample
Accession:
GSM8322619
ID:
308322619

SRA Run Selector

5.

RNA-Seq of HEK293T:C3_Taqtth_T

Organism:
Homo sapiens
Source name:
cell line
Platform:
GPL20301
Series:
GSE269592
Download data: TXT
Sample
Accession:
GSM8322618
ID:
308322618

SRA Run Selector

6.

RNA-Seq of HEK293T:B2_Taqtth_NT

Organism:
Homo sapiens
Source name:
cell line
Platform:
GPL20301
Series:
GSE269592
Download data: TXT
Sample
Accession:
GSM8322617
ID:
308322617

SRA Run Selector

7.

RNA-Seq of HEK293T:B2_siRNA_NT

Organism:
Homo sapiens
Source name:
cell line
Platform:
GPL20301
Series:
GSE269592
Download data: TXT
Sample
Accession:
GSM8322616
ID:
308322616

SRA Run Selector

8.

RNA-Seq of HEK293T:A2_siRNA_T

Organism:
Homo sapiens
Source name:
cell line
Platform:
GPL20301
Series:
GSE269592
Download data: TXT
Sample
Accession:
GSM8322615
ID:
308322615

SRA Run Selector

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db=gds|term=GSE269592[Accession]|query=2|qty=2|blobid=MCID_6734a0b705a7200ef8798490|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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