GSE263300[Accession] - GEO DataSets

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Select item 2002633001.

Mis-splicing of mitotic regulators sensitizes SF3B1-mutated human HSCs to CHK1 inhibition [scRNA-seq]

(Submitter supplied) Splicing factor SF3B1 mutations are frequent somatic lesions in myeloid neoplasms that transform hematopoietic stem cells (HSCs) by inducing mis-splicing of target genes. However, the molecular and functional consequences of SF3B1 mutations in human HSCs remain unclear. Here, we identify the mis-splicing program in human HSCs as a targetable vulnerability by precise gene editing of SF3B1 K700E mutations in primary CD34+ cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30173
2 Samples

Download data: H5AD

Series

Accession:: GSE263300

ID:: 200263300

PubMed Full text in PMC Similar studies

Select item 1000301732.

NextSeq 2000 (Homo sapiens)

Organism:: Homo sapiens

1057 Series
20389 Samples

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Platform

Accession:: GPL30173

ID:: 100030173

Select item 3081893153.

CD34+ HSPCs SF3B1 mutant

Organism:: Homo sapiens

Source name:: Hematopoietic

Platform:: GPL30173
Series:: GSE263300

Download data: H5AD

Sample

Accession:: GSM8189315

ID:: 308189315

SRA Run Selector

Select item 3081893144.

CD34+ HSPCs AAVS1 control

Organism:: Homo sapiens

Source name:: Hematopoietic

Platform:: GPL30173
Series:: GSE263300

Download data: H5AD

Sample

Accession:: GSM8189314

ID:: 308189314

SRA Run Selector

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GSE263300[Accession] (4)
GEO DataSets
CRISPRi Screen for Investigating the RORC RNA Switch Mechanisms in Jurkat Cells
CRISPRi Screen for Investigating the RORC RNA Switch Mechanisms in Jurkat Cells
CRISPRi Screen for Investigating the RORC RNA Switch Mechanisms in Jurkat Cells

BioProject
Piscirickettsia salmonis strain PSCGR01 plasmid pPsCRG01-1, complete sequence
Piscirickettsia salmonis strain PSCGR01 plasmid pPsCRG01-1, complete sequence
gi|1011400412|ref|NZ_CP013946.1|

Nucleotide
protein of unknown function DUF81 [Paraburkholderia phymatum STM815]
protein of unknown function DUF81 [Paraburkholderia phymatum STM815]
gi|184194852|gnl|jgi|Bphy_3681|gb|A 16.1|

Protein
RecName: Full=Structural polyprotein; Short=PP; Contains: RecName: Full=Precurso...
RecName: Full=Structural polyprotein; Short=PP; Contains: RecName: Full=Precursor of VP2; Short=Pre-VP2; Contains: RecName: Full=Capsid protein VP2; Contains: RecName: Full=Structural peptide 1; Short=p1; Contains: RecName: Full=Structural peptide 2; Short=p2; Contains: RecName: Full=Structural peptide 3; Short=p3; Contains: RecName: Full=Protease VP4; AltName: Full=Non-structural protein VP4; Short=NS; Contains: RecName: Full=Capsid protein VP3
gi|6226886|sp|P05844.2|POLS_IPNVJ

Protein

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