GSE166202[Accession] - GEO DataSets - NCBI

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STL-seq reveals distinct pause release and termination kinetics for promoter-proximal paused RNA polymerase II transcripts

(Submitter supplied) Despite the critical regulatory function of promoter-proximal pausing, the influence of pausing kinetics on transcriptional control remains an active area of investigation. Here, we present Start-TimeLapse-seq (STL-seq), a method that captures the genome-wide kinetics of short, capped RNA turnover and reveals principles of regulation at the pause site. By measuring the rates of release into elongation and premature termination through inhibition of pause release, we determine that pause-release rates are highly variable and most promoter-proximal paused RNA Polymerase II molecules prematurely terminate (~80%). more...

Organism:: Homo sapiens; Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL21306 GPL25244 GPL24676
32 Samples

Download data: BEDGRAPH

Series

Accession:: GSE166202

ID:: 200166202

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 1000252442.

Illumina NovaSeq 6000 (Drosophila melanogaster)

Organism:: Drosophila melanogaster

801 Series
29960 Samples

Platform

Accession:: GPL25244

ID:: 100025244

Select item 1000246763.

Illumina NovaSeq 6000 (Homo sapiens)

Organism:: Homo sapiens

17038 Series
931600 Samples

Platform

Accession:: GPL24676

ID:: 100024676

Select item 1000213064.

Illumina HiSeq 4000 (Drosophila melanogaster)

Organism:: Drosophila melanogaster

739 Series
4061 Samples

Platform

Accession:: GPL21306

ID:: 100021306

Select item 3050657945.

Organism:: Drosophila melanogaster

Source name:: Drosophila Schneider 2 cells

Platform:: GPL25244
Series:: GSE166202

Download data: BEDGRAPH

Sample

Accession:: GSM5065794

ID:: 305065794

SRA Run Selector

Select item 3050657936.

Organism:: Drosophila melanogaster

Source name:: Drosophila Schneider 2 cells

Platform:: GPL25244
Series:: GSE166202

Download data: BEDGRAPH

Sample

Accession:: GSM5065793

ID:: 305065793

SRA Run Selector

Select item 3050657927.

Organism:: Drosophila melanogaster

Source name:: Drosophila Schneider 2 cells

Platform:: GPL25244
Series:: GSE166202

Download data: BEDGRAPH

Sample

Accession:: GSM5065792

ID:: 305065792

SRA Run Selector

Select item 3050657918.

Organism:: Drosophila melanogaster

Source name:: Drosophila Schneider 2 cells

Platform:: GPL25244
Series:: GSE166202

Download data: BEDGRAPH

Sample

Accession:: GSM5065791

ID:: 305065791

SRA Run Selector

Select item 3050657909.

totRNA_S2_UT_unlab

Organism:: Drosophila melanogaster

Source name:: Drosophila Schneider 2 cells

Platform:: GPL25244
Series:: GSE166202

Download data: BEDGRAPH

Sample

Accession:: GSM5065790

ID:: 305065790

SRA Run Selector

Select item 30506578910.

STL_S2_ts_120m_2

Organism:: Drosophila melanogaster

Source name:: Drosophila Schneider 2 cells

Platform:: GPL25244
Series:: GSE166202

Download data: BEDGRAPH

Sample

Accession:: GSM5065789

ID:: 305065789

SRA Run Selector

Select item 30506578811.

STL_S2_ts_120m_1

Organism:: Drosophila melanogaster

Source name:: Drosophila Schneider 2 cells

Platform:: GPL25244
Series:: GSE166202

Download data: BEDGRAPH

Sample

Accession:: GSM5065788

ID:: 305065788

SRA Run Selector

Select item 30506578712.

Organism:: Drosophila melanogaster

Source name:: Drosophila Schneider 2 cells

Platform:: GPL25244
Series:: GSE166202

Download data: BEDGRAPH

Sample

Accession:: GSM5065787

ID:: 305065787

SRA Run Selector

Select item 30506578613.

Organism:: Drosophila melanogaster

Source name:: Drosophila Schneider 2 cells

Platform:: GPL25244
Series:: GSE166202

Download data: BEDGRAPH

Sample

Accession:: GSM5065786

ID:: 305065786

SRA Run Selector

Select item 30506578514.

Organism:: Drosophila melanogaster

Source name:: Drosophila Schneider 2 cells

Platform:: GPL25244
Series:: GSE166202

Download data: BEDGRAPH

Sample

Accession:: GSM5065785

ID:: 305065785

SRA Run Selector

Select item 30506578415.

Organism:: Drosophila melanogaster

Source name:: Drosophila Schneider 2 cells

Platform:: GPL25244
Series:: GSE166202

Download data: BEDGRAPH

Sample

Accession:: GSM5065784

ID:: 305065784

SRA Run Selector

Select item 30506578316.

Organism:: Drosophila melanogaster

Source name:: Drosophila Schneider 2 cells

Platform:: GPL25244
Series:: GSE166202

Download data: BEDGRAPH

Sample

Accession:: GSM5065783

ID:: 305065783

SRA Run Selector

Select item 30506580017.

Organism:: Homo sapiens

Source name:: Human embryonic kidney 293T cells

Platform:: GPL24676
Series:: GSE166202

Download data: BEDGRAPH

Sample

Accession:: GSM5065800

ID:: 305065800

SRA Run Selector

Select item 30506578218.

Organism:: Drosophila melanogaster

Source name:: Drosophila Schneider 2 cells

Platform:: GPL25244
Series:: GSE166202

Download data: BEDGRAPH

Sample

Accession:: GSM5065782

ID:: 305065782

SRA Run Selector

Select item 30506579919.

Organism:: Homo sapiens

Source name:: Human embryonic kidney 293T cells

Platform:: GPL24676
Series:: GSE166202

Download data: BEDGRAPH

Sample

Accession:: GSM5065799

ID:: 305065799

SRA Run Selector

Select item 30506578120.

STL_S2_ts_1.5m_2

Organism:: Drosophila melanogaster

Source name:: Drosophila Schneider 2 cells

Platform:: GPL25244
Series:: GSE166202

Download data: BEDGRAPH

Sample

Accession:: GSM5065781

ID:: 305065781

SRA Run Selector

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