GSE165631[Accession] - GEO DataSets - NCBI

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Items: 14

Select item 2001656311.

Transcriptomic profiling of oncogenic RIT1 and activated YAP1 in lung epithelial cells

(Submitter supplied) Based on xenograft data, we have found that YAP1 activation synergizes with RIT1M90I to promote lung cancer. To investigate the molecular basis for the observed functional synergy, we performed whole-genome RNA-seq in SALE cells expressing RIT1M90I and YAP15SA individually or in combination. We find that RIT1M90I and YAP15SA induced very different transcriptional states with little correlation. And, that transcripts altered by RIT1M90I were not enriched for a YAP1 gene signature, whereas YAP15SA drove activation of this signature. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
12 Samples

Download data: CSV, TXT

Series

Accession:: GSE165631

ID:: 200165631

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 1000167912.

Illumina HiSeq 2500 (Homo sapiens)

Organism:: Homo sapiens

12199 Series
349379 Samples

Platform

Accession:: GPL16791

ID:: 100016791

Select item 3050471573.

RIT1M90I_YAP5SA_3

Organism:: Homo sapiens

Source name:: RIT1M90I_YAP5SA

Platform:: GPL16791
Series:: GSE165631

Sample

Accession:: GSM5047157

ID:: 305047157

SRA Run Selector

Select item 3050471564.

RIT1M90I_YAP5SA_2

Organism:: Homo sapiens

Source name:: RIT1M90I_YAP5SA

Platform:: GPL16791
Series:: GSE165631

Sample

Accession:: GSM5047156

ID:: 305047156

SRA Run Selector

Select item 3050471555.

RIT1M90I_YAP5SA_1

Organism:: Homo sapiens

Source name:: RIT1M90I_YAP5SA

Platform:: GPL16791
Series:: GSE165631

Sample

Accession:: GSM5047155

ID:: 305047155

SRA Run Selector

Select item 3050471546.

Organism:: Homo sapiens

Source name:: YAP5SA

Platform:: GPL16791
Series:: GSE165631

Sample

Accession:: GSM5047154

ID:: 305047154

SRA Run Selector

Select item 3050471537.

Organism:: Homo sapiens

Source name:: YAP5SA

Platform:: GPL16791
Series:: GSE165631

Sample

Accession:: GSM5047153

ID:: 305047153

SRA Run Selector

Select item 3050471528.

Organism:: Homo sapiens

Source name:: YAP5SA

Platform:: GPL16791
Series:: GSE165631

Sample

Accession:: GSM5047152

ID:: 305047152

SRA Run Selector

Select item 3050471519.

Organism:: Homo sapiens

Source name:: RIT1-M90I

Platform:: GPL16791
Series:: GSE165631

Sample

Accession:: GSM5047151

ID:: 305047151

SRA Run Selector

Select item 30504715010.

Organism:: Homo sapiens

Source name:: RIT1-M90I

Platform:: GPL16791
Series:: GSE165631

Sample

Accession:: GSM5047150

ID:: 305047150

SRA Run Selector

Select item 30504714911.

Organism:: Homo sapiens

Source name:: RIT1-M90I

Platform:: GPL16791
Series:: GSE165631

Sample

Accession:: GSM5047149

ID:: 305047149

SRA Run Selector

Select item 30504714812.

SALE_parental 3

Organism:: Homo sapiens

Source name:: SALE_parental

Platform:: GPL16791
Series:: GSE165631

Sample

Accession:: GSM5047148

ID:: 305047148

SRA Run Selector

Select item 30504714713.

SALE_parental 2

Organism:: Homo sapiens

Source name:: SALE_parental

Platform:: GPL16791
Series:: GSE165631

Sample

Accession:: GSM5047147

ID:: 305047147

SRA Run Selector

Select item 30504714614.

SALE_parental 1

Organism:: Homo sapiens

Source name:: SALE_parental

Platform:: GPL16791
Series:: GSE165631

Sample

Accession:: GSM5047146

ID:: 305047146

SRA Run Selector

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