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Items: 12

1.

A suite of haploid genetic screens identifies SPRING as a novel determinant of SREBP signaling and cholesterol metabolism

(Submitter supplied) The sterol-regulatory element binding protein (SREBP) transcription factors are central transcriptional regulators of sterol- and fatty acid metabolism. Using a suite of human haploid genetic screens, we identify the SREBP Regulating Gene (SPRING; C12ORF49) as a novel regulator of this pathway. SPRING is a glycosylated Golgi-resident membrane protein. Genetic ablation of SPRING in human Hap1 cells, murine Hepa1-6 hepatoma cells, and in primary murine hepatocytes leads to a marked reduction in SREBP signaling. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
10 Samples
Download data: TXT
Series
Accession:
GSE143530
ID:
200143530

Analyze with GEO2RSRA Run Selector

2.

Illumina HiSeq 2500 (Homo sapiens)

Organism:
Homo sapiens
12160 Series
348967 Samples
Download data
Platform
Accession:
GPL16791
ID:
100016791

3.

Hap1 SPRING KO clone 26/rescue + sterols

Organism:
Homo sapiens
Source name:
Hap1 cells
Platform:
GPL16791
Series:
GSE143530
Download data
Sample
Accession:
GSM4261474
ID:
304261474

SRA Run Selector

4.

Hap1 SPRING KO clone 26/rescue - sterols

Organism:
Homo sapiens
Source name:
Hap1 cells
Platform:
GPL16791
Series:
GSE143530
Download data
Sample
Accession:
GSM4261473
ID:
304261473

SRA Run Selector

5.

Hap1 SPRING KO clone 26 + sterols

Organism:
Homo sapiens
Source name:
Hap1 cells
Platform:
GPL16791
Series:
GSE143530
Download data
Sample
Accession:
GSM4261472
ID:
304261472

SRA Run Selector

6.

Hap1 SPRING KO clone 26 - sterols

Organism:
Homo sapiens
Source name:
Hap1 cells
Platform:
GPL16791
Series:
GSE143530
Download data
Sample
Accession:
GSM4261471
ID:
304261471

SRA Run Selector

7.

Hap1 SPRING KO clone 14/rescue + sterols

Organism:
Homo sapiens
Source name:
Hap1 cells
Platform:
GPL16791
Series:
GSE143530
Download data
Sample
Accession:
GSM4261470
ID:
304261470

SRA Run Selector

8.

Hap1 SPRING KO clone 14/rescue - sterols

Organism:
Homo sapiens
Source name:
Hap1 cells
Platform:
GPL16791
Series:
GSE143530
Download data
Sample
Accession:
GSM4261469
ID:
304261469

SRA Run Selector

9.

Hap1 SPRING KO clone 14 + sterols

Organism:
Homo sapiens
Source name:
Hap1 cells
Platform:
GPL16791
Series:
GSE143530
Download data
Sample
Accession:
GSM4261468
ID:
304261468

SRA Run Selector

10.

Hap1 SPRING KO clone 14 - sterols

Organism:
Homo sapiens
Source name:
Hap1 cells
Platform:
GPL16791
Series:
GSE143530
Download data
Sample
Accession:
GSM4261467
ID:
304261467

SRA Run Selector

11.

Hap1 CTRL + sterols

Organism:
Homo sapiens
Source name:
Hap1 cells
Platform:
GPL16791
Series:
GSE143530
Download data
Sample
Accession:
GSM4261466
ID:
304261466

SRA Run Selector

12.

Hap1 CTRL - sterols

Organism:
Homo sapiens
Source name:
Hap1 cells
Platform:
GPL16791
Series:
GSE143530
Download data
Sample
Accession:
GSM4261465
ID:
304261465

SRA Run Selector

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